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冠心病与牙周病患者IL-6、TNF-a、PGE2水平相关性研究 被引量:8

Correlation of IL-6,TNF-a and PGE2 in Patients with Coronary Atherosclerosis and Periodontal Disease
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摘要 目的:探讨冠心病与牙周病患者牙龈沟液中IL-6、TNF-a、PGE2水平变化的相关性。方法:临床选择60~74岁的120例患者,分为3组,分别应用放射免疫法检测龈沟液中IL-6、TNF-a、PGE2含量。结果:与健康对照组相比,冠心病伴牙周病组及单纯牙周病组中,龈沟液中IL-6、TNF-a、PGE2含量均明显升高(P〈0.05);其中冠心病伴牙周病组龈沟液中IL-6、TNF-a、PGE2含量高于单纯牙周病组(P〈0.05)。结论:冠心病与牙周炎存在一定的相关性,伴有冠心病的牙周炎患者龈沟液内IL-6、TNF-a、PGE2水平明显升高。 Objective: To investigate the correlation of IL-6, TNF-a and PGE2 in patients with coronary atherosclerosis and periodontal disease. Methods: 120 periodontitist patient aged 60-74 were selected, detected the resorption of the IL-6, TNF-a and PGE2 in gingival crevicular fluid by radiommunoassay. Results: Compared to the healthy people, the levels of IL-6, TNF-a and PGE2 increased significantly(P〈0.05). The levels of (C+P) group were significantly higher than C group(P〈0.05). Conclusion: There may be a relationship between the two diseases and the IL-6, TNF-a and PGE2.
出处 《口腔医学研究》 CAS CSCD 2013年第10期936-938,共3页 Journal of Oral Science Research
基金 江苏省高校自然科学基金(编号:12KJB320015)
关键词 冠心病 牙周病 IL-6 TNF-A PGE2 Periodontal disease Coronary artery disease IL-6 TNF-a PGE2
作者简介 韩斐斐(1978-)女,山东人,硕士,讲师、主治医师,主要从事临床医学研究工作。 Email:Hanjg@xzmc.edu.cn
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