摘要
目的探讨CT引导经皮穿刺微波消融(PMAT)治疗肺部恶性肿瘤的临床疗效及应用价值。方法 2010年3月至2012年10月我科收治的23例周围型肺癌患者行CT引导经皮肺穿刺微波消融治疗,共31个病灶。微波频率2450MHz、功率50～70W,根据肿瘤大小、形状选择1点或2点加热。结果 23例患者均完成治疗,手术时间为5～12 min,平均8min。微波消融后即刻CT表现为病灶密度减低及CT值降低,由术前的均数52.60Hu降低为26.12Hu。获完全缓解6例,部分缓解12例,稳定3例,进展2例,有效率为78.3%。3例气胸,2例胸腔积液,15例发热,无1例针道转移。随访至2012年12月,17例患者存活,1年局部控制率为65.2%,中位无进展生存时间为14.6个月,1年、2年生存率分别为91.3%、82.6%。结论 CT引导下PMAT治疗肺肿瘤微创、安全、有效,可以提高患者的生活质量并延长生存时间。
Objective To evaluate the clinical effect and value of CT-guided percutaneous microwave ablation therapy （PMAT） for lung cancer without surgery treatment. Methods Twenty-three patients with peripheral lung cancer were treated with lo- cal anesthesia by CT-guided PMAT. There were 31 lesions in 23 patients. The microwave energy was 50-70W at a frequency of 2450MHz. The treatment was conducted by using single or two points＇ ablation emission according to the size and shape of tumor. Re- suits Operations were completed in 23 patients. The average operating time was 8min（ range ：5-12）. After microwave ablation, lower density in the ablated area was observed by CT with lower CT values. CT value was 52. 60Hu before treatment, while it reduced to 26. 12Hu ＇after treatment. There were 6 patients with complete remission, 12 cases with partial remission, 3 cases with stable, 2 cases with progress and effective rate of 78.3%. Related complications was observed including pneumothorax in 3 cases, pleural effusion in 2 cases and 15 cases with fever. No needle track implantation was observed. The mean progression free survival was 14.6months. The 1-, 2-year survival rates were 9l. 3% and 82. 6%. Conclusion PMAT is a minimaUy invasive, safe treatment and effective for lung cancer. It can improve the quality of life, prolong the survival of patients and improve the survival rate.
出处
《临床肿瘤学杂志》
CAS
2013年第7期640-643,共4页
Chinese Clinical Oncology
基金
山东省医学科学院面上项目(2012年第6号)
关键词
经皮微波消融
CT引导
肺肿瘤
Percutaneous microwave ablation therapy
CT-guide
Lung neoplasms
作者简介
通讯作者，E-mail：sunyahong0915@163．com
通讯作者，E-mail：sunyahong0915@163．com
