摘要
目的研究胰岛素泵在治疗重型颅脑损伤后血糖增高的临床应用价值。方法将80例重型颅脑损伤后血糖增高患者,随机分为两组,常规治疗组40例,应用多次胰岛素皮下注射(MSII)治疗;胰岛素泵治疗组40例,采用胰岛素泵持续皮下胰岛素输注(CSII)治疗。两组目标血糖控制在相同范围。记录两组治疗后GCS评分、达到目标血糖所需时间、胰岛素用量、低血糖发生情况及治疗后3个月GOS评分。结果两组治疗后的GCS评分、达到目标血糖所需时间、胰岛素用量、低血糖发生情况及3个月GOS评分结果各项指标的差异均具有统计学意义(P<0.05)。结论胰岛素泵治疗在重型颅脑损伤后血糖调控方面安全有效,不良反应小,能够快速平稳纠正高血糖,提高重型颅脑损伤疗效,改善患者预后。
Objective To study the value of insulin pump therapy for the hyperglycemia after severe craniocerebral trauma. Methods Total 80 patients with severe craniocerebra] injury were randomly divided into conventional treatment group （MSII group, n = 40 ） which were treated by using multi subcutaneous insulin injection, and insulin pump therapy group（ CSII group, n = 40） which were treated by using continue subcutaneous insulin infusion. In both groups, the expected range of glucose levels was controlled in the same range. The daily insulin dosage, time of controlling hyperglycemia, frequency of hypoglycemia, Glasgow co- ma scale score（GCS） after severe craniocerebral injury and Glasgow outcome score（GOS） of three months after treatment were observed and recorded. Results The daily insulin dosage, time of controlling hyperglycemia and frequency of hypoglycemia were all decreased in CSII group as compared with that in MSII group. There were significant differences in all factors between the two groups （ P 〈 0.05 ）. Conclusion The insulin pump therapy for the hyperglycemia after severe craniocerebral trauma was effective and safe with a low incidence of adverse reaction. The hyperglycemia was controlled quickly and smoothly. The treatment can obvi- ously improve the therapeutic effects and the prognosis of patients.
出处
《中华全科医学》
2013年第9期1399-1400,1471,共3页
Chinese Journal of General Practice
关键词
胰岛素泵治疗
重型颅脑损伤
血糖增高
Insulin pump therapy
Severe craniocerebral trauma
Hyperglycemia
