摘要
比较瑞格列奈组（31例）及格列美脲组（32例）联合甘精胰岛素治疗对继发性磺脲类药物失效的2型糖尿病患者糖代谢指标和胰岛β细胞分泌功能的影响。两组治疗6个月后餐前和餐后的末梢血糖及HbA1C较治疗前明显下降（均P〈0．01），但瑞格列奈（2mg tid）联合甘精胰岛素控制餐后血糖、HbA1C和改善胰岛β细胞分泌功能较格列美脲（4mg qd）联合组更好。
The effects of repaglinide combined with glargine （ n = 31 ） on glucose metabolism and β-cell function were observed in the patients with type 2 diabetes after secondary sulfonylureas failure and the results were compared with glimepiride combined with glargine （n = 32 ）. The preprandial capillary blood glucose, postprandial capillary blood glucose and HbA1C in both groups after 6-month treatment were significantly reduced as compared with those at baseline （all P 〈0.01 ）. The treatment with repaglinide（2 mg rid） plus glargine was more efficient than glimepiride （4 mg qd） plus glargine in improving β-cell function, ameliorating HbA1C and postprandial blood gJucose excursions in patients with type 2 diabetes.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2008年第2期147-148,共2页
Chinese Journal of Endocrinology and Metabolism
作者简介
Email：xu98111@163．com
