摘要
目的探讨氯沙坦对老年高血压伴高尿酸血症患者的降压和降尿酸作用。方法 40例老年高血压合并高尿酸血症患者随机分成两组。氯沙坦组20例,每天口服氯沙坦50mg。左旋氨氯地平组20例,口服左旋氨氯地平2.5～5mg/d。根据血压水平调整用药剂量,治疗4周,比较两组治疗前后收缩压、舒张压和血清尿酸水平。结果 (1)两组治疗后血压水平均明显降低(P<0.05),两组间降压疗效比较差异无统计学意义(P>0.05);(2)氯沙坦组血清尿酸水平较治疗前明显下降(P<0.05),而左旋氨氯地平组无明显变化(P>0.05),两组间差异有统计学意义。结论氯沙坦可降低老年高血压合并高尿酸血症患者血压和血尿酸水平。
Objective To study the effects of treating uricacidemia and antihypertension by losartan in elderly patients with hypertension associated hyperuricemia. Methods Selected 40 elderly patients with hypertension and hypenlricemia, and divided into two groups randomly, one group with losartan 50 mg per day, other group with levamlodipine 2.5--5 mg per day, the drug dose could be changed according the level of the blood pressure, for 4 weeks, compared the changes of serum uric acid and the blood pressure for two groups. Results （1） The systolic blood pressure and diastolic blood pressure decreased prominently in both groups after four weeks treament（P〈O.05）, but there was no significant difference between losartan group and levamlodipine group（P〉0.05）; （2） The serum uric acid had apparently reduced in losartan group after four weeks treatment（P〈O.05）, while there was not significantly reduced in levamlodipine group（P〉0.05）, difference between the two groups was statistical significance. Conclusions Losartan can reduce elderly hypertension combined hyperuricemia patients blood pressure and,blood uric acid level.
出处
《中国实用医药》
2013年第17期38-39,共2页
China Practical Medicine
