摘要
目的研究老年颈动脉狭窄与认知功能障碍及事件相关电位(ERP)的关系。方法选择80例颈动脉狭窄老年患者为观察组研究对象,选取60例无颈动脉狭窄老年人为对照组研究对象。对两组临床资料进行分析,并采用简易精神状态检查量表(MMSE)和ERP对两组认知功能进行检测。结果观察组患者原发性高血压、短暂性脑缺血发作、2型糖尿病及脑白质病变发病率显著高于对照组(P<0.05);在正常对照组、颈动脉轻、中和重度狭窄患者中,患者计算力、即刻回忆力及延迟记忆力评分逐渐减少(P<0.05);在不同颈动脉狭窄程度的研究对象中,N2和P300潜伏期及波幅差别具有统计学意义(P<0.05)。结论颈动脉狭窄是引起认知功能障碍和ERP异常的危险因素,且狭窄程度与患者病情相关。
Objective To study the correlation among elderly carotid artery stenosis, cognitive impairment and event-related poten- tial （ERP）. Methods Eighty elderly patients with carotid artery stenosis were enrolled into research group and 60 elderly controls without the disease into control group. All the clinical data were analyzed, and their cognitive function was tested by mini-mental state examination （MMSE） and ERP. Results The research group possessed significantly higher incidences of primary hyperten- sion, transient ischemic attack, type 2 diabetes mellitus and cerebral white matter lesions than the control group （ P 〈 0.05 ）. In the control group, the patients with light, medium and severe carotid artery stenosis had gradually significant decreases in the scores of calculation capacity, immediate memory and delayed memory （ P 〈 0.05 ）. In the patients with different degree of carotid steno- sis, the differences in N2 and P300 latency and amplitude were statistically significant （ P 〈 0.05 ）. Conclusion Carotid stenosis is a risk factor of cognitive dysfunction and abnormal ERP, and the degree of stenosis is associated with disorders.
出处
《临床军医杂志》
CAS
2013年第5期468-469,472,共3页
Clinical Journal of Medical Officers
关键词
颈动脉狭窄
认知功能障碍
事件相关电位
carotid artery stenosis
cognitive impairment
event related potential
作者简介
彭雪梅（1977-），女，重庆人，主治医师，医学硕士，目前主要从事神经内科临床研究
