摘要
目的观察神经节苷脂对糖尿病脑病患者认知功能的影响。方法将我院2008年3月～2010年11月收治的52例糖尿病脑病患者随机分为两组,对照组25例采用常规疗法,观察组27例加用神经节苷脂,以简易精神状态检查量表(MMSE)评分、血清神经元特异性烯醇化酶(NSE)及S-100B蛋白为观察指标比较分析两组患者的认知功能。结果治疗前两组患者的MMSE评分、血清NSE及S-100B情况比较,差异均无统计学意义(P>0.05);治疗后两组患者的MMSE评分、血清NSE及S-100B情况均得到改善,以观察组改善更为明显,组间差异具有统计学意义(P<0.05)。结论神经节苷脂能够有效改善糖尿病脑病患者的认知功能,可能与其神经细胞保护作用有关。
Objective To discuss the effect of ganglioside on the cognitive function of the patients with diabetic encephalopathy.Methods 52 cases with diabetic encephalopathy hospitalized from Mar.,2008 to Nov.,2011 were randomly divided into 2 groups： observation group（n=27） and control group（n=25）;routine treatment was applied to patients in both groups while ganlioside was added to patients in observation group;mini-mental state examination（MMSE） scores,serum neuron-specific enolase（NSE） and S-100B protein were taken as the observation indexes in comparing the cognitive function between the patients of the 2 groups.Results After treatment,the MMSE scores,serum NSE and S-100B protein of the patients in both groups were improved than those before treatment,and the improvement in observation group was more significant,the difference between the 2 groups was of statistical significance（P〈0.05）.Conclusions Ganlioside can effectively improve the cognitive function of the patients with diabetic encephalopathy,which may be related to its protective effect of neurons.
出处
《西南军医》
2011年第6期984-985,共2页
Journal of Military Surgeon in Southwest China
