摘要
目的观察氟比洛芬酯对骨折急性疼痛患者用药前后血浆前列腺素E2、5-羟色胺、缓激肽3种炎性介质及疼痛评分的影响。方法选择30名因骨折引起急性疼痛症状的住院患者作为研究对象,采取静脉滴注非类固醇类抗炎药类镇痛药氟比洛芬酯注射液进行镇痛治疗。分别于治疗前后采用简化McGill疼痛评分评价患者疼痛程度,同时采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定研究对象治疗前后血浆前列腺素E2、5-羟色胺、缓激肽水平。结果患者用药前30 min血浆前列腺素E2、5-羟色胺、缓激肽浓度均高于用药后2 h、6 h(均有P<0.001)。用药后6 h血浆前列腺素E2、5-羟色胺、缓激肽质量浓度均高于用药后2 h(均有P<0.05)。用药前30 min简化McGill疼痛评分均高于用药后2 h、6 h(均有P<0.05)、用药后6 h简化McGill疼痛评分均高于用药后2 h(均有P<0.05)。结论氟比洛芬酯可抑制骨折所致急性疼痛患者前列腺素E2、5-羟色胺、缓激肽血浆浓度并能有效减轻患者疼痛,其作用效果可持续达6 h,随时间推移镇痛效果逐渐减弱,用药后6 h没有用药后2 h效果显著。
Objective To observe the effect of flurbiprofen axetil on plasma prostaglandin E2,5-HT, bradykinin, three kinds of inflammatory mediators and pain score before and after fracture patients with acute pain medication. Methods A total of 30 inpatients with acute pain caused by fracture were selected as research objects. The intravenous drip of non- steroidal anti-inflammatory drugs and analgesic efficacy of flurbiprofen axetil injection were used for analgesia. Simplified the pain degree of patients before and after with the McGill pain score evaluation. Enzyme-linked immunosorbent assay （ELISA） nethod was used to determine plasma prostaglandin E2 , 5-HT, bradykinin before and after treatment. Results 30 min before the treatment the concentration of prostaglandin E2, 5-HT, and bradykinin, and the short-form McGill pain questionnaire （MPQ） score were significantly higher than those of 2 h and 6 h after treatment （ all P 〈 O. 05）. After 6 h, plasma prostaglandin E2,5-HT,bradykinin concentration were significantly higher than those after administration of 2 h （ all P 〈0. 05 ）. After administration of 6 h McGill pain score was higher than that 2 h after the treatment. Conclusions Flur-biprofen axetil can inhibit the fracture caused by acute pain in patients with prostaglandin E2,5-HT, bradykinin concentra-tion in plasma and can effectively reduce the pain of patients.
出处
《中华疾病控制杂志》
CAS
北大核心
2013年第5期414-416,共3页
Chinese Journal of Disease Control & Prevention
关键词
镇痛药
骨折
疼痛测定
Analgesics
Fractures
Pain measurement
作者简介
丁呈彪（1986-），男，安徽合肥人，在读硕士研究生。主要研究方向：创伤骨科学，脊柱外科学。
【通讯作者】汤健，E-mail：aytangjian@yahoo．com．cn
