摘要
目的 定量评价输血与新生儿坏死性小肠结肠炎（NEC）发病之间的联系.方法 通过电子资源数据库搜索1985年1月1日至2011年11月1日期间发表的以输血和坏死性小肠结肠炎为研究内容的中英文病例对照研究,对研究结果进行综合总结及Meta分析,以RevMan 5.0软件计算输血后发生NEC的比值比（OR）及95％可信区间（CI）,并进行敏感性分析和发表偏倚分析.结果 共纳入7篇病例对照研究文献,累计病例480例,对照2845例.用Meta分析的随机效应模型得出输血后发生NEC的比值比OR =3.35,95％ CI=（1.54,7.27）.敏感性分析表明输血48 h内发生NEC的OR=4.21,95％CI=2.17 ～8.16,而控制胎龄和出生体重等混杂因素后OR=4.29,95％ CI=1.39～ 13.24.失安全系数=263.结论 输血能增加NEC患病的危险性.
Objective To quantitatively assess the association between transfusions and the risk of necrotizing enterocolitis （NEC） in neonates.Method Both Chinese and English literature published from Jan.1985 to Nov.2011 about the case-control study of the association between transfusions and neonatal NEC were retrieved by searching the electronic resource databases.A meta-analysis was then performed on the comparison and synthesis of findings from included studies.Pooled odds ratio （OR） and 95% confidence interval （CI） were calculated using RevMan 5.0 software.Sensitivity analysis was conducted and possible publication bias was tested as well.Result A total of 7 case-control studies （480 blood transfusion cases,2845 control cases） were included.The meta-analysis with a random-effects model found a pooled OR of 3.35 （95% CI：1.54-7.27）.Sensitivity analysis showed that OR for post-transfusion NEC within 48 h was 4.21 （95% CI：2.17-8.16）.The OR was 4.29 （95% CI：1.39-13.24） after factors such as gestational age and birth weight were de-confounded.The fail-safe number was 263.Conclusion Blood transfusion can increase the risk of NEC in neonates.The clinical application of this conclusion should be cautious due to limited reports.High-quality randomized control trials are still needed for the further proof of the association between blood transfusion and neonatal NEC. Keywords：Enterocolitis,necrotizing;Blood transfusion;Infant,newborn;Meta-analysis
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2013年第5期336-339,共4页
Chinese Journal of Pediatrics
关键词
小肠结肠炎
坏死性
输血
婴儿
新生
META分析
Enterocolitis, necrotizing
Blood transfusion
Infant, newborn
Meta-analysis
作者简介
通信作者：黑明燕（Email：heiming-yan@yahoo．com.cn）
