摘要
目的:采用网状Meta分析的方法比较注射用丹参多酚酸盐、 舒血宁注射液等6种活血化瘀类中药注射剂临床用药的安全性.方法:计算机检索PubMed,the Cochrane library,CNKI,VIP,Wanfang Data数据库.各个数据库检索时间均为2008年1月至2018年5月.采用stata15.0软件进行网状Meta分析.结果:最终纳入文献48篇,总用药患者2868例.在安全性方面,注射用丹参多酚酸盐(OR=0.67,95%CI[0.37,1.21])、 丹参川芎嗪(OR=0.87,95%CI[0.45,1.69])、 灯盏细辛(OR=1.46,95%CI[0.40,5.32])、 疏血通(OR=0.42,95%CI[0.22,0.80])、 舒血宁(OR=1.40,95%CI[0.71,2.78])、 血塞通(OR=0.65,95%CI[0.34,1.24]).其安全性由高到低的排列顺序为疏血通>血塞通>注射用丹参多酚酸盐>丹参川芎嗪>舒血宁>灯盏细辛.结论:通过网状meta分析可知,疏血通注射液在临床用药时不良反应发生的可能性最低,安全性最好;灯盏细辛不良反应发生的可能性最高,安全性最差.
Objective To systematically analyse the clinical safety of six traditional Chinese medicine(TCM)injections that promote blood circulation to remove blood stasis in our hospital,including salvianolate,shuxuening,among others,using network meta-analysis.Methods The PubMed,Cochrane Library,China National Knowledge Infrastructure,VIP database of Chinese journals and Wanfang Data databases were searched using computer-based search methodsfor articles published between January 2008 and May 2018.The network meta-analysis was performed by Stata version 15.0(StataCorp LLC,College Station,TX,USA).Results A total of 48 studies were included.There were 2868 patients who were treated with drugs.It was demonstrated that the safety of drugs was as follows:salvianolate(OR 0.67[95%CI 0.37-1.21]);Danshen Chuanxiongqin(OR 0.87[95%CI 0.45-1.69]);Dengzhan Xixin(OR 1.46[95%CI 0.40-5.32]);Shuxuetong(OR 0.42[95%CI 0.22-0.80]);Shuxuening(OR 1.40[95%CI 0.71-2.78])and Xuesaitong(OR 0.65[95%CI 0.34-1.24]).The safety sequence from high to low of TCM injection for promoting blood circulation and removing blood stasis was Shuxuetong>Xuesaitong>Salvianolate>Danshen Chuanxiongqin>Shuxuening>Dengzhan Xixin.Conclusion Based on network meta-analysis,it was concluded that Shuxuetong was associated with the fewest probability of adverse reactions and the best safety profile,while Dengzhan Xixin was associated with the highest probability of adverse reactions and the worst safety profile.
作者
程金泉
石庆平
丁峰
余美玲
孔令提
王灿
CHENG Jinquan;SHI Qingping;DING Feng;YU Meiling;KONG Lingti;WANG Can(Department of Pharmacy,the First Hospital Affiliated of Bengbu Medical College,Bengbu 233004,China;School of Pharmacy,Bengbu Medical College,Bengbu 233030,China)
出处
《中国民族民间医药》
2019年第13期139-146,共8页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
安徽省教育厅2014年度高等教育振兴计划人才项目[皖教秘人(2014)181号]
基于真实世界研究与循证评价相结合的中药注射液上市后安全性再评价(YWJKJJHKYJJ-B17402-B02)
关键词
活血化瘀类中药注射剂
不良反应
安全性
网状Meta分析
Traditional Chinese Medicines that Promote Blood Circulation and Remove Blood Stasis
Adverse Reactions
Safety
Network metaanalysis
作者简介
程金泉(1991-),男,汉族,硕士研究生,研究方向为医院安全合理用药监测与评估,E-mail:2274527179@qq.com;通信作者:石庆平(1974-),男,汉族,硕士,主任药师,教授,研究方向为临床用药评估、中药注射剂安全性评价,E-mail:sir shi@126.com
