摘要
目的:观察桃仁、红花不同配比的血府逐瘀汤后处理对缺血再灌注心肌保护的临床研究。方法:120例冠心病患者随机分为对照组(A组)和血府逐瘀汤后处理组,血府逐瘀汤组又按桃仁、红花不同配比(1∶1、4∶3、3∶4)分B方组、C方组、D方组,各组患者在PCI术前、后予常规药物治疗,血府逐瘀汤后处理各组在此基础上,于PCI术前3 d和术后4 d应用桃仁、红花不同配比的血府逐瘀汤,每天1次。检测各组患者酶学动态变化及SOD、MDA含量、术后24 h内心律失常、术后3个月随访主要心血管不良事件。结果:血府逐瘀汤后处理各组肌酸磷酸激酶、肌酸磷酸激酶同工酶峰值及MDA含量明显低于A组(P<0.05)、SOD明显高于A组(P<0.01);血府逐瘀汤后处理各组的恶性心律失常和主要心血管不良事件发生率比A组明显减少。结论:桃仁、红花不同配比的血府逐瘀汤后处理对PCI术后的心肌都具有保护作用,并可进一步改善预后,其中以桃仁与红花的比值4∶3的C方组疗效最佳。
Objective ：The aim of this study is to explore the ischemic myocardium protective effects of pharmacological postconditioning of Xuefu Zhuyu decoctions consisted by different ratios of peach kernel and safflower carthamus. Meth- ods：120 patients with coronary artery disease （CHD）were randomly separated into four groups （n = 40）. Group A was control group, group B was treated with Xuefu Zhuyu decoction which was consisted by peach kernel and safflower cartha- mus at the ratio of 1 ： 1, group C was treated with Xuefu Zhuyu decoction which was consisted by peach kernel and saf- flower carthamus at the ratio of 4 ： 3, and group I） was also treated with Xuefu Zhuyu decoction in which the ratio of peach kernel and safflower carthanms is 3 ： 4. The patients in each group were given the normal medical therapies before and af- ter percutaneous coronary intervention（PCI）. Besides, during the three days before PCI and the four days after PCI, the patients in group B, C and I） were additionally given the respective Xuefu Zhuyu decoction per day. The myocardial en- zyme, superoxide dismutase（ SOD）, malondialdehyde（MDA） and the arrhythmia in 24 h after PCI were detected, and the major cardiovascular end point events were followed up in the following three months. Results ： The peaks of CK and CK - MB and the concentrations of MAD in group B, C and D were significantly lower than those in group A （ p 〈 0.05 ） , but the SOD in group B, C and D were high than that in group A. Furthermore, compared with group A, the incidences of malig- nant arrhythmia and major cardiovascular end point events were also reduced in the other three groups. Conclusion：The three different Xuefu Zhuyu decoctions are all benefit to protect the ischemic myocardium and could improve the prognosis of CHD patients. And in these three Xuefu Zhuyu decoctions,the one consisted of peach kernel and safflower carthamus at the ratio of 4 ： 3 is considered as the best anagraph.
出处
《中华中医药学刊》
CAS
2013年第4期783-785,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药科学重点研究计划资助项目(2011ZA107)
关键词
血府逐瘀汤
冠心病
经皮冠状动脉介入术
心肌保护
Xuefu Zhuyu decoction
coronary artery disease
percutaneous coronary intervention
myocardium protection
作者简介
作者简介：彭放（1964-），男，浙江绍兴人，主任医师，研究方向：药物后处理对缺血再灌注心肌保护的临床和科研。
