摘要
目的了解鲍曼不动杆菌在医院内的分布状况与耐药谱,指导临床有效预防并合理用药。方法对中国中医科学院望京医院2009年至2011年三年间临床送检标本中,分离的254株鲍曼不动杆菌,采用纸片扩散法进行药敏试验,并使用WHONET 5.5对药敏试验数据进行分析统计。结果 254株鲍曼不动杆菌主要来源于痰标本,占90.59%。对哌拉西林和头孢曲松耐药率很高,分别为79.38%和89.33%,对头孢他啶、头孢吡肟、阿米卡星、妥布霉素、以及两种加β内酰胺酶抑制剂的复合抗生素的耐药率也都在51%～57%,多粘菌素B和头孢哌酮/舒巴坦对其具有较强的抗菌活性,耐药率分别为0.63%和17.88%。结论鲍曼不动杆菌是目前医院感染重要的条件致病菌,并且多重耐药率高,应引起广泛关注并严格按照临床用药方案进行抗生素使用,防止耐药性的进一步产生和院内传播。
Objective To identify clinical infection distribution and antibiotic resistance spectrum of Acinetobact- er baumannii, and to guide effective clinical prevention and rational drug use. Methods The 254 Aeinetobacter baumannii strains clinically isolated from the year of 2009 to 2011 were investigated by drug susceptibility using the disk diffusion method, and the results were statistically analyzed by WHONET 5.5. Results The 254 Acine- tobacter baumannii isolates were mostly in sputum specimens, andthe ratios were about 90.5%. The resistance rates to piperacillin and ceftriaxone were 79.38% and 89.33% respectively. The antibiotic resistance rates of ceftazidime, cefepime, amikacin, tobramycin, and two different types of plus 13- lactamase inhibitor compound were about 51%-57 %. Polymyxin B and cefoperazone / sulbactam had strong antibacterial activity, and the re- sistance rates were 0.63% and 17.88%. Conclusion Acinetobacter baumannii is a domain opportunistic patho- gen in hospital infection with high multiple drug resistance. It should be widespread emphasized with clinical regimen of antibiotic use in order to prevent further spread of the drug resistance within hospital.
出处
《标记免疫分析与临床》
CAS
2013年第2期99-101,共3页
Labeled Immunoassays and Clinical Medicine
关键词
鲍曼不动杆菌
耐药性
抗生素
Acinetobacter baumannii
Resistance
Antibiotics
作者简介
陈永德，男，本科，副主任检验医师。E-mail：wjcydy@sina．com
通讯作者：郭洁，女，本科，副主任技师，主要从事临床微生物及免疫学检验研究。E-mail：gj7176@sina．com
