摘要
目的观察阿托伐他汀联合小檗碱对稳定型心绞痛(SAP)患者血脂水平的影响。方法将200例SAP患者随机分为对照组(n=100)和观察组(n=100),每组100例,对照组给予阿托伐他汀10mg(qd),观察组在对照组基础上增加小檗碱300mg(tid),随访1个月。比较两组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清肌酐(Scr)、谷氨酰氨基转移酶(ALT)、肌酸激酶(CK)的差异。结果治疗1个月后,与对照组相比,观察组TC[(3.38±1.05)mmol/Lvs.(4.24±1.07)mmol/L];TG[(1.20±0.62)mmol/Lvs.(1.42±0.73)mmol/L];LDL-C[(2.10±0.71)mmol/Lvs.(2.58±0.61)mmol/L];ALT[(22.32±11.66)U/Lvs.(34.46±12.87)U/L]水平下降更显著(P<0.05);HDL-C水平升高无差异,Scr和CK未见差异。结论小剂量阿托伐他汀联合小檗碱具有更强的调脂效应,对肝功能的影响更小。
Objective To observe the influence of berberine combining atorvastatin on blood fat level in patients with stable coronary heart disease.Methods The patients（n =200）were randomly divided into control group and observation group（each n =100）.The control group was given atorvastatin（10 mg,4 times a day）,and observation group was additionally given berberine（300 mg,3 times a day）.All groups were followed up for one month.The difference in total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein-cholesterol（LDL-C）,high-density lipoprotein-cholesterol（HDL-C）,serum creatinine（Scr）,alanine aminotransferase（ALT）and creatine kinase（CK）were compared between two groups.Results After treatment for one month,the levels of TC,TG,LDL-C and ALT decreased significantly in observation group compared with control group（3.38 ± 1.05 vs.4.24 ± 1.07;1.20 ± 0.62 vs.1.42 ± 0.73;2.10 ± 0.71 vs.2.58 ± 0.61;22.32 ± 11.66 vs.34.46 ± 12.87;all P〈0.05）.There was no difference in HDL-C increase,Scr and CK observed between two groups.Conclusion Berberine combining atorvastatin has higher regulation effect on blood lipid and lower influence on liver function.
出处
《中国循证心血管医学杂志》
2013年第1期19-20,共2页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
广东省韶关市科技计划项目[韶科(卫)2010-11]
关键词
小檗碱
阿托伐他汀
血脂
冠状动脉疾病
Berberine
Atorvastatin
Blood fat
Coronary artery disease
作者简介
通讯作者：万槐斌，E-mail：vanhymn@yahoo．com．cn
