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地佐辛复合丙泊酚用于无痛肠镜麻醉的临床观察 被引量:12

Clinical observation of dezocine and propofol combination intravenous injection for painless colonoscopy
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摘要 目的:观察地佐辛联合丙泊酚用于门诊无痛肠镜检查的安全性、可行性及有效性。方法:选择本院ASAⅠ~Ⅱ级80例纤维结肠镜检患者,随机分为A组(地佐辛复合丙泊酚组,n=40)和B组(芬太尼复合丙泊酚组n=40)。观察两组患者术前、镜过结肠脾曲及术后SpO2、HR、MAP、RR、意识消失时间(睫毛反射消失)、术中体动、苏醒时间、视觉模拟评分(VAS)、丙泊酚总用量、随访患者满意度。结果:和B组相比,A组患者苏醒时间缩短,术中术毕不良反应发生率明显低于芬太尼组,术中生命体征更加平稳。结论:地佐辛复合丙泊酚用于无痛肠镜检查和治疗镇痛效果及镇静效果确切,安全性高,不良反应少,是一种可行,有效的无痛肠镜麻醉方法。 Objective: To investigate the safety,feasibility and effectiveness of dezocine combined with propofol used for painless colonoscopy examination and treatment.Methods: Select 80 cases colonoscopy patients who is in ASAⅠ~Ⅱ in our hospital and then randomly divide into group A(dezocine combined with propofol group,n=40) and group B(fentanyl combined with propofol group n=40).Observe two patients,mirror over the splenic flexure of colon,SpO2,HR,MAP,RR after operation,the time of loss of consciousness(loss of eyelash reflex),body movement in operation,recovery time,VAS,and the total dosage of propofol.Finally follow up patients' satisfication.Results: Compared with group B,the patients in group A decrease the recovery time.The incidence rate of adverse reaction was significantly lower than that in the fentanyl group in operation and after operation.Vital signs in group A were more stable.Conclusion: Dezocine combined with propofol used in painless colonoscopy examination,treatment of pain and sedative effect has a good effect,high security and fewer adverse reactions.So it is a feasible,effective anesthesia method of painless colonoscopy.
出处 《河南医学研究》 CAS 2012年第4期429-431,共3页 Henan Medical Research
关键词 地佐辛 芬太尼 丙泊酚 无痛肠镜 dezocine fentanyl propofol painless colonoscopy
作者简介 程静(1985-),女,河南安阳人,在读硕士研究生,研究方向:麻醉与阵痛。 通讯作者:董铁立(1959-),男,博士生导师,主任医师,教授。E-mail:tlddtl@163.com。
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参考文献6

  • 1庄心良;曾因明.现代麻醉学[M]北京:人民卫生出版社,2003483.
  • 2Shoichi U,Takahisa G,Katsuo T. Emergence agitation after sevoflurane versus propofol in pediatric patients[J].Anesthesia and Analgesia,2000,(08):563-566.
  • 3陈新谦;金有豫;汤光.新编药物学[M]北京:人民卫生出版社,2011163-179.
  • 4陈红,朱跃坤.丙泊酚复合地佐辛在人工流产术中的应用[J].实用临床医药杂志,2011,15(21):123-124. 被引量:24
  • 5Sun Z T,Yang C Y,Cui Z. Effect of intravenous dezocine on fentanyl-induced vcough during general anesthesia induction:a5doubleblinded,prospective,randomized,controlled trial[J].Anesthesia and Analgesia,2011,(06):860-863.
  • 6刘俊,徐越峰.地佐辛应用于瑞芬太尼静脉麻醉术后痛觉过敏观察[J].中国医疗前沿,2009,4(24):15-16. 被引量:153

二级参考文献8

  • 1VanNatta M E, Rex D K. Propofol aione titrated to sedation versus propofol in combination with opioids and/or benzodi- azepines and titrated to moderate sedation for edonoscopy[J ]. Am J Gastroenterol, 2006, 101(10) : 2209.
  • 2刘俊杰 赵俊.现代麻醉学[M].北京:人民卫生出版社,1999.324.
  • 3Trafton JA,Abbadie C,Marek K,et a1.Postsynaptic signaling via the[mu]-opioid receptor:Responses of dorsal horn neurons to exogenous opioids and noxious stimulation[].The Journal of Neuroscience.2000
  • 4Borgland SL.Acute opioid receptor desensitization and tolerance:Is there a link[].Clinical and Experimental Pharmacology and Physiology.2001
  • 5Hansen EG,Duedahl TH,Romsing J,et a1.Intraoperative remifentanil might influence pain levels in the immediate postoperative period after major abdominal surgery[].Acta Anaesthesiologica.2005
  • 6Kissin I,Brown PT,Bradley EL Jr.Magnitude of acute tolerance to opioids is not related to their potency[].Anesthesiology.1991
  • 7Kissin I,,Thompson JP,Rowbotham DJ.Remifentanil:an opi-oid for the21st centrury[].British Journal of Anaesthesia.1996
  • 8周少丽,马武华,陈秉学.异丙酚对心血管系统的影响[J].国外医学(麻醉学与复苏分册),2002,23(6):329-331. 被引量:173

共引文献174

同被引文献91

  • 1王振军,黄莚庭.应进一步加强我国结肠癌的基础研究[J].中华医学杂志,2004,84(9):705-707. 被引量:22
  • 2王建民,陈猛,温立勇,刘永梁,宋丽莉,王秋红.丙泊酚、咪唑安定与芬太尼复合麻醉在结肠镜检查中的临床观察[J].牡丹江医学院学报,2006,27(2):25-28. 被引量:10
  • 3Loniskar A, Greenblatt DJ. Pharmacokinetics of Dezocine, a New Analgesic Effect of Dose and Route of Administration[J]. Eur J Clin Phannacol, 1986,30( 1 ) : 121-123.
  • 4Wilson JM,Cohen RI,Kezer EA,et al. Single-and multiple- dose pharmacokinetics of dezocine in patients with acute or chronic pain[J].J Clin Pharmacol, 1995,35 (4) : 398-403.
  • 5Zacny JP,Lichtor JI,De Wit H. Subjective,behavioral, and physiologicresponses to intravenous dezocine in healthy volun- teers[J].Anesth Anal1992,74(4) : 523-530.
  • 6Strain EC,Preston KL,Liebson IA. Opioid antagonist effects of dezocine in opioid-dependent humans[J].Clin Pharmacol Ther, 1996,60(2) :206-217.
  • 7Aisenberg J. Gastrointestinal endoscopy in patients taking novel oral anticoagulants[J]. Gastroenterol Hepatol (N Y), 2014,10(2):117-119.
  • 8Effenberger M1, Steinle H, Offner FA, et al. Holes in gastric mucosa in upper gastrointestinal endoscopy [J]. Eur J Gastroenterol Hepatol,2014,26(6):676-678.
  • 9Tronnier VM, Raschc D. Neuroablative procedures in pain therapy[J].Schmerz, 2009, 23(5):531-541.
  • 10Zahn PK, Sabatowski R, Schug SA, et al. Paracetamol for perioperative analgesia old substance new insights [J]. Anaesthesist,2010,59(10):940-952.

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