摘要
乌药烷型倍半萜及其二聚体是一大类具有cis,trans-3/5/6三并环特殊骨架的天然产物,主要是从金粟兰科植物中分离得到.大多数乌药烷型倍半萜及其二聚体具有显著的生物活性,如抗真菌、对B细胞有毒性介导的免疫抑制及对延迟整流钾电流有选择性的抑制作用等.综述了国内外有机化学家对该类天然产物的全合成研究进展.
Lindenane-type sesquteripenoids and their dimers, mainly isolated from chloranthaceae, are a big family of natural products, which possess novel polycyclic framework embedded with a sterically congested cyclopentane （ring B）, an unusual trans-5/6 ring junction, and an angular methyl group. Moreover, many of them exhibited impressing bioactivities, for example remarkable antifungal activity, toxicity-mediated immunosuppression against B cells, and selective inhibition on the delayed rectifier K＋current. In this review, the progress in the total syntheses of lindenane-type sesquiterpenoids and their dimmers is summarized.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2013年第1期90-100,共11页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.20872098,21021001,21172154)
国家重点基础研究发展规划(973计划,No.2010CB833200)~~
关键词
乌药烷
倍半萜
二聚体
全合成
lindenane
sesquiterpenoid
dimer
total synthesis
作者简介
E-mail： chembliu@scu.edu.cn
