摘要
将苯乙胺衍生的手性膦-亚磷酰胺酯配体应用在Rh-催化α-烯醇酯膦酸酯的不对称氢化反应中,考察了配体结构及反应条件对反应结果的影响,并在优化的条件下研究了各种底物的适用范围,产物的对映选择性最高>99%ee.
A series of phosphine-phosphoramidite ligands derived from commercially available,inexpensive chiral 1-phenylethylamine were employed in the Rh-catalyzed asymmetric hydrogenation of various α-enol ester phosphonates.The results indicated that the ligand（Sc,Sa）-2b bearing a Me-group on amino moiety exhibited similar enantioselectivity but superior catalytic activity to（Rc,Ra）-THNAPhos.Excellent enantioselectivities（up to 99% ee） and high catalytic activity（S/C up to 5 000） have been achieved in the hydrogenation of various β-alkyl and β-aryl substituted substrates,demonstrating the high potential of this phosphine-phosphoramidite ligand in the preparation of optically active α-hydroxyphosphonates
出处
《分子催化》
EI
CAS
CSCD
北大核心
2012年第6期487-492,共6页
Journal of Molecular Catalysis(China)
基金
国家自然科学基金(No.20972156)
关键词
不对称催化
铑
膦-亚磷酰胺酯配体
α-烯醇酯膦酸酯
氢化
asymmetric catalysis
rhodium
phosphine-phosphoramidite ligand
α-enol ester phosphonate
hydrogenation
作者简介
胡娟，女，生于1975，硕士研究生．
通讯联系人，E—mail：xiangping@dicp．812．cn．
