摘要
合成了一种新型可重复使用的含手性联萘酚的C3对称树状小分子配体(L1),并将L1用于诱导二乙基锌和芳基醛的不对称加成反应.获得的二级醇最高的对映选择性为91%ee,产物最高收率达99%.反应完成后,只需经过简单的萃取和洗涤过程就可实现对配体L1高回收率的回收.配体L1重复使用5次其催化活性和对映选择性没有明显变化.
A novel,recoverable C3-symmetric dendritic small molecular ligand（ L1） containing BINOL has been synthesized to conduct the enantioselective addition of diethylzinc to aromatic aldehydes. The optically active s econdaryalcohols were obtained with up to 91% ee and up to 99% yield. After the reaction was finished,the dendritic ligand L1 was recovered with a high yield by simple extraction and washing process. The recycled dendritic ligand was reused for five times without loss of catalytic activity as well as enantioselectivity.
出处
《分子催化》
EI
CAS
CSCD
北大核心
2015年第4期299-306,共8页
Journal of Molecular Catalysis(China)
基金
国家自然科学基金(No.21172186)资助项目
国家教育部博士点基金(No.20134301110004)
关键词
C3对称
芳香醛
二乙基锌
不对称加成
C3-symmetric
aromatic aldehyde
diethylzinc
enantioselective addition
作者简介
朱维君（1987-），男，硕士生．E—mail：94951655@qq．com．
通讯联系人，E-mail：nfyang@xtu．edu．cn．
通讯联系人，E-mail：nfyang@xtu．edu．cn．
