摘要
目的:检测心力衰竭患者血清脑钠肽(BNP)及N末端脑钠肽前体(NT-proBNP)水平,分析其与心功能的相关性以及对心力衰竭的诊断价值。方法:选取我科治疗的慢性心衰患者58例并按照NYHA心功能分级,比较不同心功能分级的患者血清BNP、NT-proBNP的水平及其与射血分数等指标的相关性,并分析BNP与NT-proBNP的诊断价值。结果:①各心功能分级间采用单因素方差分析发现,BNP、NT-proBNP随心功能分级增加而增加(P<0.05),不同心功能分级的组间比较发现,除III级与IV级BNP、NT-proBNP、LVEF、6min步行距离差异不明显(P>0.05),其余组间比较均具有显著性差异(P<0.05)。②经比较发现,BNP、NT-proBNP均与LVEF、6min步行距离呈负相关,而与左室舒张末期内径、左室收缩末期内径呈正相关。③NT-proBNP诊断效力高于BNP。结论:血清BNP和NT-proBNP可作为评估左心室功能不全和左心室结构改变的临床指标。
To study the levels of serum BNP （Brain natriuretic peptide, BNP） and NT-proBNP （N-terminal pro-brain natriuretic peptide, NT-proBNP） in patients with CHF （chronic heart failure, CHF）, to investigate their diagnostic values and analyze their relativity with different NYHA heart function. Methods： Totally, 58 patients with CHF were selected. Serum BNP and NT-proBNP were measured with automatic enzyme immunoassay system and chemiluminescence immunoassay respectively. Comparing the relation- ship between BNP and NT-proNBP in different stages of heart function and analysis their diagnosis value. Results： ①The level of BNP, NT-proBNP were significantly increased with the stages of heart function grow up （P〈0.05）. But the difference of BNP, NT-proBNP LVEF and 6min walk test between NYHA III and NYHA IV were not obviously （P〈0.05） ②The level ofBNP, NT-proBNP were nega-tively correlated with LVEF and 6min walk test and were positively correlated with LVEDD and LVESD. ③ The diagnostic value of NT-proBNP is higher than BNP. Conclusion： Both plasma BNP and NT-proBNP can be used to evaluate the heart function of patients with heart failure, and are useful tools for diagnosis of CHF.
出处
《现代生物医学进展》
CAS
2012年第32期6325-6327,6334,共4页
Progress in Modern Biomedicine
关键词
脑钠肽
N末端脑钠肽前体
心力衰竭
Brain natriuretic peptide
N-terminal pro-brain natriuretic peptide
NT-proBNP
Heart failure
作者简介
刘军（1976-），男，主治医师，本科，研究方向：心血管内科
通讯作者：龙达（1972-），男，硕士剧主任医师研究方向：心血管内科
