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重性抑郁症患者视觉空间旋转信息加工的性别效应及事件相关电位研究

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摘要 目的探讨性别因素对重性抑郁症患者视觉空间旋转信息加工的脑电生理机制的影响。方法对来自本院46例重性抑郁症患者和39名健康被试者(对照组)进行心理旋转任务的事件相关电位测定。测量其P500潜伏期、波幅及其错误数和反应时。结果(1)与对照组相比,男性患者组[正像(37.2±6.2)%VS(12.4±3.2)%,(753.2±92.2)msVS(572.5±85.3)ms;镜像(21.3±5.3)%VS(24.3±4.1)%,(928.6±96。2)InSVS(654.6±89.6)ms]和女性患者组[正像(38.1±7.3)%VS(20.3±3.6)%,(756.7±93.5)msVS(732.3±81.7)ms;镜像(21.6±6.1)%VS(33.6±5.2)%,(932.3±98.5)msVS(865.3±93.1)ms]错误率正像显著升高,镜像显著降低,正镜像反应时显著延迟(P〈0.05)。与男性相比,女性患者组正像和镜像错误率、反应时差异无统计学意义(P〉0.05)。(2)与对照组相比,男性患者组[正像(7.3±2.1)μVVS(10.4±3.6)斗V;镜像(7.6±2.1)μVVS(6.5±1.8)μV]和女性[正像(6.84-2.4)μVVS(8.8±2.7)斗V;镜像(6.4±2.0)IxVVS(5.3±2.0)IxV]P500波幅正像显著降低,镜像显著升高(P〈0.05);男女患者组P500潜伏期正像延迟(P〈0.05),镜像差异无统计学意义(P〉0.05)。与男性相比,女性患者组正像和镜像P500波幅、潜伏期差异均无统计学意义(P〉0.05)。结论重性抑郁症患者视觉空间旋转信息加工受损,且性别效应消失,其中男性患者受损程度大于女性患者。提示女性的视觉空间旋转能力低的特性在一定程度上能对空间旋转信息加工机制起保护作用。
出处 《中国医师杂志》 CAS 2012年第11期1502-1505,共4页 Journal of Chinese Physician
基金 军队中医药科研专项课题(IOZYX108)
作者简介 通信作者:杨来启,Email:ericcst@yahoo.cn
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