摘要
目的探讨抑郁症和精神分裂症患者心理旋转能力的差异性，为临床鉴别精神疾病提供特异性客观指标。方法2011年3至9月对来自解放军第三医院30例抑郁症患者、30例精神分裂症患者和28名健康志愿者进行心理旋转任务测定。测量其错误率、正像反应率和反应时。结果（1）错误率：与对照组（正像：29％±10％，镜像：32％±3％）相比，抑郁症组正像升高（31％±13％，P〈0．05），镜像降低（22％±4％，P〈0．01）；精神分裂症组，正像降低（27％±9％，P〈0．05），镜像升高（42％±2％，P〈0．01）。（2）正像反应率：与对照组（50％±9％）相比，抑郁症组降低（38％±12％，P〈0．01），精神分裂症组升高（60％±9％，P〈0．01）。（3）反应时：与对照组[正像（602±25）ms，镜像（606±14）ms]相比，抑郁症组，正像和镜像反应时延长[正像（653±23）ms，镜像（714±13）ms，P〈0．01]；精神分裂症组，正像和镜像反应时缩短[正像（571±180）ms，镜像（587±11）ms，P〈0．01）。结论抑郁症患者心理旋转能力受损，其正像严重受损，镜像得到了补偿；精神分裂症患者心理旋转能力也受损，其镜像严重受损，正像得到了补偿，提示正镜像旋转能力可以相互转化，即其可能是一个状态性指标。心理旋转能力受损可为临床鉴别诊断精神疾病提供特异性客观指标。
Objective To compare the mechanism of depressive disorder and schizophrenia＇ mental rotation ability so as to provide specific objective clinical indicators for identifying mental illness. Methods Thirty depressive disorder （15 males, 15 females）, 30 schizophrenia （15 males, 15 females） and 28 healthy participants （ 14 males, 14 females） were tested to perform mental rotation tasks with the letter F and R graphics. The subjects were required to decide whether the stimulus was a normal or a mirror version of an alphabet letter presented in different views and angular orientations. The mouse left key was pressed for a normal and the mouse right button for a mirror. Results （ 1 ） Error rate ： As compared with the normal control group （normal： 29% ±10% , mirror： 32% ±3% ） , the normal error rate was significantly higher while the mirror error rate significantly lower in depressive disorder （normal： 31%±13%, mirror： 22% ±4%, P 〈 0.01 ） ; the normal error rate was significantly lower while the mirror error rate significantly higher in schizophrenia （normal： 27% ±9% , mirror ： 42% ±2% , P 〈 0. 01 ）. （2） Normal reaction rate ： As compared with the normal control group （50% ＋ 9% ）, the normal reaction rate was significantly lower in depressive disorder （38% ±12%, P 〈 0. 01 ） and significantly higher in schizophrenia （60% ±9%, P 〈 0. 01 ）. （3） Response time： As compared with the normal control group（ normal （602 ±25 ） ms, mirror （606 ±14） ms）, the normal and mirror response durations were both significantly longer in depressive disorder（ normal （ 653 ±23 ） ms, mirror （ 714 ±13 ） ms, P 〈 0.01 ） while significandy shorter in schizophrenia（normal （571 ±18） ms, mirror （587 ±11 ） ms, P 〈 0. 01 ）. Conclusion Normal mental rotation ability is severely impaired in depressive disorder, but its mirror counterpart becomes compensated.In schizophrenia, mirror mental rotation ability is severely impaired, but its normal counterpart becomes compensated. It hints that normal and mirror rotation ability may be interchangeable so as to serve as a state index. The impairment of mental rotation ability impaired can be used as specific objective clinical indicators of identifying mental illness.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2012年第13期915-919,共5页
National Medical Journal of China
基金
基金项目：军队中医药科研专项课题（10ZYX108）
关键词
抑郁症
精神分裂症
特异性
Depressive disorder
Schizophrenia
Specificity
作者简介
通信作者：杨来启，Email：ericcst@yahoo．cn
