摘要
目的:评价尼可地尔联合阿托伐他汀对经皮冠状动脉介入治疗(PCI)患者的心肌保护作用。方法:收集在心内科拟进行介入治疗的患者共85例,随机分为观察组(43例)和对照组(42例)。观察组在术前(5±2)d开始服用尼可地尔(10mg,tid)联合阿托伐他汀钙(20mg,qd)治疗,对照组给予常规药物治疗。术后继续服用4周。观察术中心绞痛发作及心电图变化情况;检测术前、术后12h及24h磷酸肌酸激酶同工酶浓度;观察术前、术后4周的心脏功能变化。结果:观察组介入治疗术中心绞痛发生率显著低于对照组,差异有统计学意义(P<0.01)。术中球囊扩张时观察组出现缺血性心电图改变的比例小于对照组(P<0.05)。PCI术后各时点观察组CK-MB值明显低于对照组(P<0.05),术后4周观察组左室射血分数值高于对照组[(66.4±5.3)%比(62.9±8.2)%,P<0.05]。结论:PCI围手术期应用尼可地尔联合阿托伐他汀可显著减少术中心绞痛发作,减轻心肌损伤,进一步改善PCI术后的左心功能。
OBJECTIVE To evaluate the myocardial protection of nicorandil plus atorvastatin treatment during percutaneous coronary intervention（PCI）.METHODS A total of eighty-five patients undergoing selected PCI were randomly divided into the observation group（n=43） and control group（n=42）.The observation group received oral nicorandil（10 mg,tid） combined with atorvastatin（20 mg,qd） for（5±2） days before coronary angiography treatment,the control group was given routine drug therapy.The daily routine dosage was continued for 4 weeks after the procedure.For each patient,the angina pectoris attacks,CK-MB,electrocardiogram and echocardiogram were recorded.RESULTS Angina did not occur in observation group during the procedure but occurred in 10 patients in the control group（P0.01）.The changes of ST-segment and T wave during balloon dilatation in PCI procedure were less in the observation group（P0.05）.The CK-MB activity was significantly lower in the observation group compared with the control group in different observing time-point,respectively（P0.05）.Ejection fraction in the observation group was higher than that in the control group after operation 4 weeks [（66.4±5.3）% vs（62.9±8.2）%,P0.05].CONCLUSION Nicorandil plus atorvastatin treatment could reduce the frequency of angina pectoris attacks and myocardial damage during PCI,and improve the left ventricular function during follow-up period after PCI.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第21期1749-1752,共4页
Chinese Journal of Hospital Pharmacy
作者简介
李昌，男，学士，副主任医师。研究方向：心血管临床及介入，电话：13377865269
