摘要
[目的 ]探究上海石棉厂接触温石棉工人 40年来恶性肿瘤的发病情况。 [方法 ]为评估恶性肿瘤的危险程度 ,采用回顾性队列研究的方法 ,对 5 5 1位工作于该厂的工人从 195 8年至 1998年进行回顾研究。 [结果 ]以上海市区居民恶性肿瘤的发病率和死亡率进行比较。恶性肿瘤的发病危险程度显著上升 ,男性全肿瘤 (RR =4 19)和肺癌 (RR =7 6 7) ,女性全肿瘤 (RR =2 15 )和肺癌 (RR =2 6 )。男性肺癌的比例死亡比为 1 8(PMR =1 8)。 [结论 ]石棉工人肺癌和鼻咽癌的高发与接触石棉有关。
Objective] This study is to explore incidence of malignant tumor in workers exposed to chrysotile asbestos in Shanghai Asbestos Products Factory in past 40 years.[Methods] In order to evaluate the risk of malignant tumor,a retrospective cohort study was conducted by following up 551 workers who primarily worked in this factory since 1958.[Results] Compared to incidence rate and mortality for cancers among residents in Shanghai urban,a raised risk of malignant tumor,all cancer (RR=4.19) and lung cancer (RR=7.67) for men,all cancer (RR=2.15) and lung cancer (RR=2.6) for women was observed in workers.Proportionate mortality ratio of lung cancer for men is 1.8 (PMR=1.8).[Conclusion] Lung cancer and nasopharyngeal cancer occurred more frequently in the workers exposed to asbestos,which could be a risk factor contributing to carcinogenesis.
