摘要
目的观察矽肺患者氧化应激指标的变化,探讨矽肺发生发展的机制。方法对100例对照组、200例接尘组,32例矽尘作业观察对象(原诊断0+患者)组及130例矽肺组分别测定血清中氧化应激指标:超氧化物歧化酶(SOD)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)、一氧化氮合酶(NOS)及脂质过氧化物丙二醛(MDA)含量。结果与对照组比较,接尘组与矽肺组NO水平、GSH-Px活力均明显升高,SOD水平明显降低(P<0.05,P<0.01);与对照组、接尘组比较,矽肺组T-AOC、NOS、MDA均明显升高(P<0.05,P<0.01);矽肺组较接尘组GSH-Px活力明显升高(P<0.01)。与观察对象组和Ⅰ期矽肺组比较,Ⅲ期矽肺组GSH-Px活力明显升高(P<0.05)。Pearson相关分析显示血清中GSH-Px水平与矽肺分期、分组、接尘工龄、工种呈显著正相关(P<0.01)。结论机体氧化和抗氧化系统的失衡与矽肺的发生发展有关;对氧化应激指标的监测有利于预测矽肺发病和评估预后。
[Objective]To investigate the change of indicators of oxidative stress in serum of patients with silicosis,and explore the mechanism of the development of silicosis.[Methods]Indicators of oxidative stress in serum including superoxide dismutase（SOD）,nitric oxide（NO）,serum glutathione peroxidase（GSH-Px）,total antioxidant capacity（T-AOC）,nitric oxide synthase（NOS）,and lipid malondialdehyde（MDA） were determined in 100 cases of control group,200 cases of dust-exposed group,32 cases of observed group（the original diagnosed 0 ＋ patients） and 130 cases of silicosis group.[Results] Compared with the control group,NO,GSH-Px were significantly increased,and SOD were decreased significantly in dust-exposed group and silicosis group（P〈0.05,P〈0.01）.Compared with the control group and dust-exposed group,T-AOC,NOS,MDA levels in silicosis group were significantly increased.（P〈0.05,P〈0.01）.GSH-Px in the silicosis group was increased significantly（P〈0.01） than that in dust-exposed group.GSH-Px were increased in phase Ⅲ silicosis group than that in observation group and phaseⅠ silicosis group（P〈0.05）.Pearson correlation analysis showed serum GSH-Px had a significant positive correlation with silicosis staging,grouping,seniority exposed to dust,type of work（P〈0.01）.[Conclusion]The imbalance of oxidative and anti-oxidation system is related with the occurrence and development of silicosis.The monitoring on oxidative stress indicators is benefit for the prediction and prognosis assessment of silicosis.
出处
《职业与健康》
CAS
2012年第15期1818-1820,共3页
Occupation and Health
基金
无锡市卫生科研基金项目(项目编号:XM0909)
关键词
矽肺
氧化应激
发病机制
Silicosis
Oxidative stress
Pathogenesis
作者简介
赵道昆，男，副主任医师，主要从事职业病临床工作。
通讯作者：缪荣明，Email：jstzmrm@163．com
