摘要
目的探讨老年患者肺部感染后脂蛋白(a)水平变化规律,为该病诊断、治疗提供依据。方法应用胶乳凝集比浊法测定老年肺部感染患者血清脂蛋白(a)水平及治疗后变化。结果感染组急性感染期脂蛋白(a)异常率为80.0%,脂蛋白(a)水平为(389.17±279.32)mg/L,对照组异常率为5.0%,脂蛋白(a)水平为(103.51±76.04)mg/L,感染组明显高于对照组(P<0.05);经系统治疗后老年肺部感染患者脂蛋白(a)水平为(160.04±129.62)mg/L,较感染组明显降低(P<0.05);老年肺部感染患者脂蛋白(a)变化规律与CRP等经典炎症指标相一致。结论作为急性时相反应蛋白,脂蛋白(a)参与老年肺部感染的病理生理过程,可作为老年肺部感染患者诊断、治疗判断的综合指标。
OBJECTIVE To study the potential role of lipoprotein（a） in senile patients with pulmonary infections and provide the evidence for clinical diagnosis and treatment.METHODS The levels of serum Lp（a） were measured by latex agglutination turbidimetric method in senile patients with pulmonary infections,the change after the treatment was observed as well.RESULTS The percentage of the abnormal Lp（a） was 80% in the infection group at the acute infection stage,5% in the control group;the level of Lp（a） was（389.17±279.32）mg/L,the control group（103.51±76.04）mg/L,the infection group was significantly higher than the control group（P〈0.05）;after the systematic treatment the level of serum Lp（a） of the senile patients with pulmonary infections was（160.04±129.62）mg/L,significantly decreased as compared with the infection group（P〈0.05）;the variation tendency of Lp（a） was consistent with the classic inflammation markers such as CRP.CONCLUSION These findings indicate that the Lp（a）,as is the acute response protein,may involve in the pathogenesis of pulmonary infections in senile patients,it may be regarded as a monitoring index of diagnosis and treatment of pulmonary infections in the senile patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第13期2799-2801,共3页
Chinese Journal of Nosocomiology
关键词
老年
肺部感染
脂蛋白(a)
临床研究
Senile patients
Pulmonary infections
Lipoprotein（a）
Clinical research
