环境因素与Tau蛋白的异常磷酸化被引量：8

Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease

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摘要神经纤维缠结是阿尔茨海默病(Alzheimer's disease,AD)的重要病理特征之一,其发生发展因素一直是相关研究领域的热点问题.神经纤维缠结由异常磷酸化的Tau蛋白错误折叠、聚集所形成,因此对诱发Tau蛋白异常磷酸化的因素进行探究显得尤为重要.Tau蛋白异常磷酸化逐渐形成神经缠结是AD早期发生的病理过程之一,本文就Tau蛋白异常磷酸化发生的环境影响因素进行了讨论. Neurofibrillary tangles （NFTs） are regarded as one of the major pathological features of Alzheimer＇s disease, and are composed of misfolded and aggreagted Tau protein with hyperphosphorylation. But the mechanism of Tau hyperphosphorylation still remains to be clarified. This review summarized the roles of endogenous and exogenous factors in the induction of Tau hyperphosphorylation. The level of some factors and the hyperphosphorylation of Tau could be used as biomarkers for the early processing of AD.

作者魏艳苗君叶刘缨

机构地区脑与认知科学国家重点实验室中国科学院生物物理研究所中国科学院研究生院

出处《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2012年第8期778-784,共7页 Progress In Biochemistry and Biophysics

基金国家重点基础研究发展计划(973)资助项目(2012CB911004)~~

关键词环境因素阿尔茨海默病 TAU蛋白异常磷酸化 endogenous and exogenous factors, Alzheimer＇s disease, Tau protein, abnormal phosphorylation

分类号 Q26 [生物学—细胞生物学] Q291 [生物学—细胞生物学]

作者简介通讯联系人．Tel：010-64875055，E—mail：liuy@moon．ibp．ac．cn

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环境因素与Tau蛋白的异常磷酸化被引量：8

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环境因素与Tau蛋白的异常磷酸化被引量：8