摘要
目的观察神经节苷脂联合依达拉奉治疗急性脑梗死的疗效及对炎症因子的影响。方法 2009年8月～2011年8月,156例急性脑梗死患者随机分为两组,观察组78例给予神经节苷脂联合依达拉奉治疗,对照组78例给予血栓通治疗,对比观察两组的临床疗效以及TNF-α、IL-6和CRP水平的变化。结果观察组的总有效率为88.5%,明显高于对照组的69.2%(P﹤0.05)。与治疗前比较,两组治疗后TNF-α、IL-6和CRP水平明显降低,差异均有统计学意义(P﹤0.05)。观察组治疗后TNF-α、IL-6和CRP水平明显低于同期对照组,两组比较差异有统计学意义(P﹤0.05)。结论神经节苷脂联合依达拉奉对急性脑梗死患者进行治疗,能够明显提高临床疗效,降低TNF-α、IL-6和CRP水平,值得临床推广应用。
OBJECTIVE To observe the effect of ganglioside combined with edaravone in treatment of acute cerebral infarction and its effect on inflammatory cytokines. METHODS From August 2009 to August 2011, 156 cases of acute cerebral infarction patients were classified into two groups. The observation group with 78 cases were treated with ganglioside combined with edaravone. The control group with 78 cases were treated with Xueshuantong. The clinical effect and the changes of TNF-α, IL-6 and CRP between the two groups were compared. RESULTS The total effective rate in observation group was 88.5%, which was significantly higher than that of control group with 69.2% （P﹤0.05）. Compared with pretreatment, the levels of TNF-α, IL-6 and CRP in both two groups were significantly decreased （P﹤0.05）. Moreover, the levels of TNF-α, IL-6 and CRP in observation group were significantly lower than those in control group （P﹤0.05）. CONCLUSION Ganglioside combined with edaravone in treatment of acute cerebral infarction can improve clinical effect, and degrade the levels of TNF-α, IL-6 and CRP, which can be applied in clinic.
出处
《现代预防医学》
CAS
北大核心
2012年第12期3182-3183,3185,共3页
Modern Preventive Medicine
作者简介
喻莉（1963-）．女，本科，主治医师，研究方向：神经内科
