摘要
目的 研究判断甲状腺髓样癌 (MTC)患者手术是否成功以及残余病灶定位的方法。 方法 对 14例MTC术后的患者进行了钙负荷 降钙素激发试验 ,并检测血癌胚抗原 (CEA)、胃泌素(GST)、肠血管活性肽 (VIP) ,同时对降钙素增高的患者进行生长抑素受体 (somatostain receptor,SS R)核素显像。 结果 14例患者钙负荷 降钙素激发试验后降钙素峰值均升高 (9 3～ 2 2 49 8μg/L) ,其中 7例患者降钙素基础值异常升高 (6 9 7～ 16 6 9 1ng/L) ,峰值更高 ;对其 7例进一步进行SS R显像后 ,均显像阳性 ,而 14例患者的CEA、VIP及GST测定值均在正常范围。 结论 对MTC术后的患者进行钙负荷 降钙素激发试验十分必要 ,特别是对血降钙素轻度增高的患者 ,可及时判断体内是否有残余病灶 ;SS R显像有助于病灶的定位 ;CEA、VIP及GST测定对MTC(包括伴有腹泻症状者 )术后监测意义不大。
Objective[WT5”BZ] To assess whether calcium stimulation test or somatostain receptor(SS R) imaging could early detect remnants after removal of medullary thyroid carcinoma(MTC). [WT5”HZ]Methods[WT5”BZ] Calcitonin stimulation (calcium element 3 mg/kg weight, i.v.10 min),carcino embryonic antigen(CEA),gastrin(GST) and vasoactive intestinal peptide(VIP) were tested in 14 patients with postoperative MTC. SS R imaging was used to localize the remnants after removal of MTC in patients with elevated calcitonin. [WT5”HZ]Results[WT5”BZ] Calcitonin stimulation test showed that the peak value of serum calcitonin was elevated in all patients, of whom 7 had the elevated vatue of basic calcitonin and peak calcitonin. In the 7 patients, SS R imaging showed normal CEA, GST and VIP. [WT5”HZ]Conclusions[WT5”BZ] It is necessary for patients after removal of MTC to perform calcitonin stimulation test for detecting remnants early. SS R imaging may be useful for localizing remnants and metastatic foci. CEA,GST and VIP are not significant in monitoring MTC after operation. [WT5”HZ]
出处
《中华外科杂志》
CAS
CSCD
北大核心
2000年第1期19-21,共3页
Chinese Journal of Surgery
关键词
甲状腺肿瘤
甲状腺髓样癌
SS-R
Thyroid neoplasms
Carcinoma,medullary
Receptor,somatostain
Calcitonin
Radionuclide imaging
