摘要
目的 :观察霉酚酸酯 (MMF)在预防肾移植术后近期 (3个月 )急性排斥反应 (AR)的情况。方法 :将 112例患者随机分成 2组 ,MMF(2 .0 g/d)组和硫唑嘌呤 (Aza)组。两组患者均同时接受相似剂量的环孢素 A和类固醇激素治疗。结果 :观察 3个月 ,MMF组 6 0例 ,AR发生率为 16 .7% (10 /6 0 ) ,Aza组 5 2例 ,AR发生率为 42 .3%(2 2 /5 2 ) ,两组差异有极显著意义 (P <0 .0 1)。 MMF组 5例出现血白细胞、血小板等不同程度下降 ,3例出现腹泻 ,在 MMF减量或停药后均恢复正常 ,未见有 MMF引起的肝、肾功能异常病例 ;Aza组有 9例出现肝功能损害。结论 :MMF具有预防和减少肾移植术后近期 AR效果 ,MMF的安全性可靠 ,副作用轻且为可逆性。
Purpose:To observe the effect of mycophenolate mofetil (MMF) on prevention of acute renal transplantation rejection in the near period of postoperation. Methods: 112 cases of renal transplant recipients were divided into two groups at random .Group MMF ( 2.0 g/d)and Group Aza. Recipients of the two groups simultaneously received similar doses of CsA and steroids. Results:With in the three months observation, the incidence of acute rejection were 16.7 % (10/60) in Group MMF and 42.3 % (22/52) in Group Aza respectively (P< 0.01 ). Of the 60 cases of recipients in Group MMF,5 cases emerged reduction of WBC and platelet,3 cases with diarrhea, which all recovered after rduction or discontinuation of MMF. No case of liver or renal dysfunction were found in Group MMF while 9 cases of recipients of liver dysfunction in Group Aza. Conclusions:MMF can prevent and reduce acute renal transplantation rejection and the side effects of MMF are slight and reversible.
出处
《临床泌尿外科杂志》
2000年第1期19-21,共3页
Journal of Clinical Urology
关键词
霉酚酸酯
肾移植
移植物排斥
免疫抑制剂
Mycophenolate mofetil Kidney transplantation Graft rejection Immunosuppressive agents
