摘要
目的:系统评价在中国紫河车治疗卵巢功能早衰的有效性和安全性。方法:采用Cochrane系统评价法,检索Cochrane图书馆临床对照试验数据库,All EBM Reviews,Embase,PubMed,MEDLINE和CNKI等数据库,纳入紫河车治疗卵巢功能早衰的随机/半随机对照试验,不限语种。评价纳入研究的方法学质量,应用RevMan 5.0.25软件对有关数据进行Meta分析。结果:本研究共纳入相关文献2篇,135例患者,纳入研究的方法学质量整体偏低。与西药组相比,紫河车结合西药人工周期组月经改善率高于对照组,差异有统计学意义(RR=1.47,95%CI:1.19~1.82,P=0.000 4),血清雌二醇(E2)水平改善明显高于西药组,差异有统计学意义[加权均数差(WMD)=-42.29,95%CI:-56.45^-28.13,P<0.000 01]。其他方面差异均无统计学意义。结论:紫河车结合西药人工周期疗法比单纯的西药人工周期疗法改善卵巢功能早衰患者的月经恢复和血清激素水平的疗效好。但目前尚无充分证据证明,单纯紫河车治疗国人卵巢功能早衰的有效性和安全性优于激素治疗等西医治疗方法,尚待更多严格设计的随机对照试验、样本量较大的临床试验加以证实和重新评价。
Objective： To assess the effectiveness and safety of Placenta Hominis in treatment of premature ovarian failure of Chinese people. Methods：A systematic review and meta-analysis of the randomized/semi-randomized controlled trials was designed to study Placenta Hominis used for treating premature ovarian failure. Articles were searched from The Cochrane Library, All EBM Reviews, EMBASE, PUBMED, MEDLINE, CNKI, etc. RevMan 5.0.25 recommended by The Cochrane Collaboration was used to conduct this systematic review and meta-analysis. Results：Two trials including 135 patients were included. The methodological quality of two studies was low. The menses recovery rate in the group treated with Placenta Hominis combined with artificial menstrual cycle was significantly higher than that in the control group treated with simple artificial menstrual cycle （RR=1.47,95%C1：1.19-.82,P=0.000 4）.The change of serum E2 level in the group treated with Placenta Hominis combined with artificial menstrual cycle was also better than that in the control group （WMD=-42.29,95%CI：-56.45-28.13,P〈0.000 01）. Conclusions：In the treatment of premature ovarian failure, Placenta Hominis combined with artificial menstrual cycle had a relatively higher menses recovery rate and better serum E2 level than the control group. It can not be concluded at present that Placenta Hominis is better than the hormonal treatment. More evidence from the high quality, randomized placebo controlled trials is needed to assess the effectiveness and safety of traditional Chinese herbals, such as Placenta Hominis, in treating premature ovarian failure.
出处
《国际生殖健康／计划生育杂志》
CAS
2012年第2期99-104,共6页
Journal of International Reproductive Health/Family Planning
关键词
紫河车
卵巢功能早衰
系统评价
中国
PLACENTA HOMINIS
Ovarian failure, premature
Systematic review
China
作者简介
通信作者：许良智，E-mail：liangzxu@126．com
