摘要
血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)家族是一类多功能的细胞因子,在血管生成和淋巴管生成中具有直接和间接的调控作用,可促进内皮细胞增殖、促进血管生成以及增加血管的通透性。VEGF/VEGFR轴由多重配基和受体质量叠加交错组成,并且受体与配基结合具有专一性,在不同的细胞中具有不同的细胞类型表达和功能.启动VEGF信号通路,触发了一个网状的信号过程,从而促进血管内皮细胞生长、转移和存活。进来研究发现,VEGF的一个重要作用表现为可动员内皮祖细胞从骨髓向远处转移从而形成新生血管,因而有必要设计和发展针对这一途径的抑制因子。随着研究的深入,VEGF促进肿瘤血管生成的作用和与人类癌症的发病机制的关系是确定的,因此。
Vascular Endothelial Growth Factor（VEGF） family is a multifunctional kind of cytokine,which has direct or indirect effect in angiogenesis and lymphangion generation.It can promote proliferation of endothelial cells,angiogenesis and increase the permeability of blood vessels.The VEGF/VEGF-receptor axis is composed of multiple ligands and receptors with overlapping and distinct ligand-receptor binding specificities,cell-type expression,and function.Activation of the VEGF signaling pathway triggers a network of signaling processes that promote endothelial cell growth,migration,and survival from pre-existing vasculature.A recently research show an important role of VEGF has emerged in mobilization of endothelial progenitor cells from the bone marrow to distant site neovascularization.So,it is necessary to design and develop the inhibitory factors against the target pathway.With the research going on,the role of VEGF promoting angiogenesis in tumor is related to the mechanism of cancer in human,and inhibiting the pathway of VEGF is seemed an important effective way to resist cancer.
出处
《现代生物医学进展》
CAS
2012年第4期777-779,701,共4页
Progress in Modern Biomedicine
基金
黑龙江省科技攻关计划(GC07C35105)
作者简介
通讯作者：王晓民（1956-），男，主任医师，主要研究方向：泌尿系统肿瘤的诊治，电话：0451-82576896E—mail：Xiaomin-Wang20001@yahoo．com．cn
