摘要
目的:通过对不同剂量甲基强的松龙与地塞米松治疗急性视神经炎的研究,比较治疗急性视神经炎的治疗效果。方法:对62例共97眼急性视神经炎患者,随机分为3组,分别给予甲基强的松龙0.5g/d、1.0g/d,地塞米松10～15mg/d静脉滴注3～6d,随后均口服强的松40mg/d,根据视力及瞳孔反应情况缓慢减量,观察各组视力,瞳孔对光反应、相对性传入性瞳孔障碍程度和激素不良反应。结果:甲基强的松龙1.0g/d静滴治疗的急性视神经炎患者视力恢复比地塞米松快(P=0.046),而甲基强的松龙0.5g/d静脉滴注治疗者视力恢复程度与地塞米松无统计学差异(P=0.103)。结论:甲基强的松龙1.0g静脉滴注治疗急性视神经炎效果较好,建议尽早给予患者使用大剂量激素治疗并维持较长的治疗时间。
Objective： To evaluate the efficacy of corticosteroids in acute optic neuritis through study of different doses of intravenous methylprednisolone and dexamethasone.Methods： 62 cases with 97 eyes diagnosed as acute optic neuritis were randomly divided into 3 groups.They were treated with 0.5 g/d,1.0 g/d methylprednisolone and 10~15 mg/d dexamethasone,intravenous infusion of 3~6 d,followed by oral prednisone 40 mg/d.Then,reduced the doses slowly based on their visual acuity,relative afferent pupillary defect（RAPD） and the side effect of corticosteroids.Results： Recovery of visual acuity in 1.0 g/d methylprednisolone group was faster than that in dexamethasone group（P=0.046）,but there was no significant difference between dexamethasone group and 0.5 g/d methylprednisolone group（P=0.103）.Conclusion： Intravenous methylprednisolone 1.0 g/d is an effective treatment of acute optic neuritis.It is important to give patients large doses of hormone as soon as possible for better curative effects and maintaining a longer medicine efficacy time.
出处
《华夏医学》
CAS
2011年第4期424-426,共3页
Acta Medicinae Sinica
关键词
急性视神经炎
甲基强的松龙
地塞米松
acute optic neuritis
intravenous methylprednisolone
dexamethasone
作者简介
王冬梅（1974-），女，甘肃人，2008年广西医科大学眼科研究生毕业，主治医师。
