摘要
自1985年首次报道采用葡聚糖硫酸钠(dextran sulphate sodium,DSS)制备出仓鼠溃疡性结肠炎模型以来,已有大量研究证明DSS结肠炎模型与人类溃疡性结肠炎相似.该模型的病因、临床症状、病理改变及治疗应答均与人类UC相类似;对于研究UC病因、发病机制及UC相关增生和肿瘤,确定治疗手段有重要意义.虽然DSS模型制作简单;但该过程受到多个因素的影响:DSS浓度、给药时间、DSS相对分子质量和动物种属等.如不能正确处理这些因素,很难制造出成功的DSS结肠炎模型.本文主要针对DSS造模影响因素及尚需我们进一步研究和探讨的问题作综述如下.
The animal models of dextran sulphate sodium （DSS）-induced colitis have demonstrated several correlations with human ulcerative colitis （UC） since the first report of DSS-induced colitis in hamsters in 1985.These animal models have similarities to human UC in etiology,pathology,pathogenesis and therapeutic response,and are deemed suitable for investigating the pathogenesis and therapeutic options of UC and UCrelated dysplasia-adenocarcinoma sequence.Although induction of colitis with DSS is relatively cheap and simple,the development of this model is influenced by many factors,such as DSS concentration,administration duration,DSS molecular weight and animal species.These factors are important for successful development of DSS-induced colitis.In this paper we summarize factors influencing the development of animal models of DSS-induced colitis.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第36期3666-3671,共6页
World Chinese Journal of Digestology
基金
上海市科研基金资助项目
No.08cz017
国家自然科学基金资助项目
No.30873261~~
关键词
炎症性肠病
溃疡性结肠炎
葡聚糖硫酸钠
影响因素
Inflammatory bowel disease
Ulcerative colitis
Dextran sulphate sodium
Influencing factors
作者简介
温红珠，硕士研究生，主要从事中医药防治胃肠疾病的研究．
通讯作者：郝微微，副主任医师，200032，上海市徐汇区宛平南路725号，上海中医药大学附属龙华医院消化内科hao2364@hotmail．com电话：021—64385700—6423
