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涎腺腺样囊性癌中Survivin与nm23表达的研究 被引量：2

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摘要 目的探讨Survivin和nm23在涎腺腺样囊性癌(SACC)发生、发展及淋巴转移过程中的作用。方法采用免疫组化ABC法检测8例正常腮腺及38例SACC石蜡标本中Survivin和nm23的表达。结果 Survivin蛋白阳性染色和nm23阳性染色标准是细胞胞质中可见棕黄色颗粒或团块。Survivin在正常涎腺组织中表达阳性率为100.0%,在SACC其阳性率为66.7%,两组比较P<0.05。nm23在正常涎腺组织中表达阳性率为100.0%,在SACC其阳性率为58.3%,两组比较P<0.05。Survivin、nm23蛋白的表达与SACC病理类型、发病年龄、性别及肿瘤大小均不相关。Survivin阳性率与淋巴结转移呈正相关,nm23阳性率与淋巴结转移呈负相关。在涎腺SACC组织中Survivin与nm23蛋白两者间呈负相关。结论 Survivin蛋白和nm23蛋白在涎腺SACC的发生、发展及淋巴转移过程中起重要作用。
作者 史建洁 董福生 任贵云
机构地区 河北大学附属医院 河北医科大学口腔医院
出处 《山东医药》 CAS 北大核心 2011年第52期70-72,共3页 Shandong Medical Journal
关键词 涎腺 腺样囊性癌 SURVIVIN NM23 淋巴转移
分类号 R739.8 [医药卫生—肿瘤]
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参考文献8

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共引文献1

同被引文献46

  • 1刘晋,于皆平,王晓玲,周晓东,于红刚.环氧合酶-2和血管内皮生长因子-C与胃癌淋巴管转移[J].中华内科杂志,2004,43(11):841-844. 被引量：13
  • 2王旭,王洁,董福生,董玉英,侯亚丽.COX-2及survivin在涎腺多形性腺瘤中表达的定量研究[J].山东医药,2005,45(12):1-2. 被引量：4
  • 3魏温涛,刘勤江.上皮钙黏蛋白、P53和Bcl-2在涎腺腺样囊性癌组织中的表达及与肺转移、神经浸润的相关性[J].兰州大学学报（医学版）,2007,33(3):17-19. 被引量：7
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山东医药
2011年 第52期

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