摘要
目的:探讨急性脑梗死患者血浆神经元特异性烯醇酶(neuron-specificenolase,NSE)的动态变化及预后意义。方法:选择急性脑梗死患者68例,分别于发病后3d内(68例)、第7天(66例)、第14天(65例)和第30天(64例)采集血标本,应用酶联免疫吸附法测定血浆NSE水平,检测结果与35名正常对照者比较;并探讨脑梗死患者血浆NSE水平与脑梗死体积及临床神经功能改善的相关性。结果:脑梗死患者发病3d内、第7天血浆NSE水平明显高于对照组,以3d内变化尤著;预后不良组血浆NSE水平在3d内(12例)、第7天(10例)、第14天(9例)各时间点均明显高于预后良好组(56例)。66例脑梗死患者第7天的脑梗死体积与其发病3d内、第7天血浆NSE水平呈正相关,相关系数分别为0.83、0.75(均P<0.001)。64例脑梗死患者第30天神经功能缺损评分减少值与3d内、第7天血浆NSE水平呈负相关,相关系数分别为-0.41(P<0.001)、-0.37(P<0.01)。结论:急性脑梗死患者早期血浆NSE水平明显升高,血浆NSE的动态变化可反映脑梗死的严重程度及其近期预后。
Objective To investigate the dynamic changes of the plasma neuron-specific enolase(NSE) level in patients with acute cerebral infarction(CI) and its significance for prognosis. Methods Sixty-eight patients with CI were included into this study. The concentrations of NSE were measured by ELISA within the first 3 days(68 cases), on the 7th day(66 cases),14th day(65 cases) and 30th day(64 cases) after the onset, respectively, and their results of plasma NSE level were compared with 35 healthy controls. The correlation among the plasma NSE level, the size of the infarction, and the neurological function in the patients were explored. Results Compared with those of 35 healthy controls, plasma NSE levels of the patients were increased significantly within the first 3 days and on the 7th day, and especially within the first 3 days. The patients with worse prognosis had higher levels of plasma NSE within the first 3 days (12 cases), on the 7th day (10 cases) and on the 14th day (9 cases) than those with good prognosis (56 cases). There was a positive correlation between the size of the infarction and plasma NSE levels within the first 3 days and on the 7th day, with the correlation coefficients of 0.83 and 0.75 respectively (P<0.001). The decreased clinical neurological deficit scores on the 30th day after the attack were negatively correlated with plasma NSE levels within the first 3 days and on the 7th day, with the correlation coefficients of -0.41 (P<0.001) and -0.37 (P<0.001) respectively. Conclusions The plasma levels of NSE increase obviously in the early stage of the CI. The dynamic changes of the plasma NSE levels in the patients with CI might reflect to some extent the severity of the neuronal damages and the near outcome.
出处
《诊断学理论与实践》
2004年第5期330-333,共4页
Journal of Diagnostics Concepts & Practice
