摘要
目的:探讨羟丙基-β-环糊精对人参皂苷Rg1溶解度的影响。方法:用HPLC测定人参皂苷Rg1的含量,设计正交试验考察羟丙基-β-环糊精浓度、温度、搅拌时间,单因素考察pH对人参皂苷Rg1溶解度的影响,对制备的样品进行冻融稳定性考察。结果:羟丙基-β-环糊精质量浓度40%,温度40℃,搅拌时间12 h,pH 7时,人参皂苷Rg1溶解度为353.20 g.L-1,样品冻融稳定性好。结论:羟丙基-β-环糊精对人参皂苷Rg1溶解度有很大的提高。
Objective：To investigate influence of hydroxypropyl-β-cyclodextrin on solubility of ginsenoside Rg1.Method： The content of ginsenoside Rg1 was determined by HPLC,orthogonal test was used to study on concentration of hydroxypropyl-β-cyclodextrin、temperature and stirring time,single factor test was used to analysis the influence of pH to solubility of ginsenoside Rg1,and investigated freeze-thaw stability of samples prepared in these conditions;Result： Optimum conditions for hydroxypropyl-β-cyclodextrin improving solubility of ginsenoside Rg1 were as follows：concentration of hydroxypropyl-β-cyclodextrin 40%,temperature 40 ℃,stirring time 12 h.When pH was 7,solubility of ginsenoside Rg1 was 353.20 g·L-1.Freeze-thaw stability of samples was good.Conclusion： Solubility of ginsenoside Rg1 had greatly improved by using hydroxypropyl-β-cyclodextrin.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第21期17-19,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
校企联合研究开发项目(20090402)
作者简介
[第一作者]缪菊连，硕士，讲师，从事药物制剂研究，Tel：15125282836，E-mail：sun007119@sina．com
[通讯作者]黄照昌，学士，工程师，从事天然药物的开发与利用研究，Tel：15125022320，E—mail：hze@sina．com
