摘要
背景:组织工程的发展为神经缺损的修复提供了可能,种子细胞与导管支架制成的复合体是构建组织工程神经的核心。目的:从干细胞的组织工程应用及构建具有良好生物相容性的导管支架材料角度,探索如何更好的修复神经损伤。方法:以"干细胞,神经损伤,修复,神经导管,神经支架材料"为中文关键词,以"stem cells,nerve damage,repair,nerve guide conduit material,scaffold materials,nerve tissue engineering"为英文关键词,采用计算机检索CNKI和Medline数据库1996-01/2011-01有关不同来源干细胞和导管支架材料修复神经缺损的相关文章,排除重复研究或Meta分析类文章,筛选纳入30篇文献进行评价。结果与结论:移植神经干细胞可以在神经系统存活、增殖、迁移,在不同部位分化为相应的细胞,因此给神经修复领域带来新的希望。另外,随着生物材料的发展,神经导管材料修复神经缺损也取得了优良的效果,具有良好的应用前景。将神经干细胞复合导管可降解生物材料有望能更好的满足神经支架的要求,达到修复和重建的目的。
BACKGROUND：Development of tissue engineering can realize the repair of nerve defects.Combination of stem cells and nerve guide conduit scaffold is the core to construct tissue-engineered nerves.OBJECTIVE：To investigate how to better repair nerve defects based on tissue-engineering application of stem cells and construction of nerve conduit scaffolds with good biocompatibility.METHODS：CNKI and Medline databases were searched for articles addressing stem cells from different sources and nerve conduit scaffolds for repair of nerve defects published from 1996-01 to 2011-01.The keywords were ＂stem cells,nerve damage,repair,nerve guide conduit,nerve scaffold materials＂ in Chinese and ＂stem cells,nerve damage,repair,nerve guide conduit material,scaffold materials,nerve tissue engineering＂ in English.Repetitive studies or Metal analysis were excluded,and finally 30 articles were included.RESULTS AND CONCLUSION：The transplanted neural stem cell can survive,proliferate and migrate in the nervous system,and can be differentiated into corresponding cells at different regions,which brings a new hope for nerve repair.In addition,with the development of biomaterials,nerve conduit materials have also made excellent results in the repair of nerve defects,and have a good prospect.Neural stem cells combined with biodegradable nerve conduit materials are expected to better meet the requirements of nerve scaffolds to achieve the purpose of nerve repair and reconstruction.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第27期5119-5122,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
作者简介
王苏平★，男，1958年生，硕士，硕士生导师，主任医师，主要从事干细胞移植治疗神经系统损伤性疾病和神经系统各种疑难杂症的临床研究。yiyuanyisheng@yeah．net
