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PUMA与肿瘤的相关性研究 被引量：1

Correlation of PUMA to tumor
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摘要 PUMA是BCL-2蛋白家族的促凋亡成员之一,可抑制肿瘤发生,并诱导肿瘤细胞凋亡。PUMA表达增高可提高肿瘤细胞对化学药物及辐射的敏感性,其表达缺失可减轻正常细胞对辐射的损伤。 PUMA is a pro-apoptotic member of the BCL-2 family.PUMA can inhibit the occurrence of tumor and induce apoptosis of tumor cells.The up-regulated PUMA can increase the sensitivity of tumor cells to chemical substances and radiation,and the deletion of PUMA can protect the normal cells from radiation injury.
作者 曹岩 曾常茜
机构地区 大连大学医学院辽宁省生物有机化学重点实验室
出处 《基础医学与临床》 CSCD 北大核心 2011年第9期1067-1069,共3页 Basic and Clinical Medicine
基金 辽宁省教育厅高校科研项目(2009T003)
关键词 PUMA 肿瘤 凋亡 PUMA tumor apoptosis
分类号 R730.2 [医药卫生—肿瘤]
作者简介 通信作者（corresponding author）：zengchangqian@163．com
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二级参考文献15

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同被引文献11

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  • 7Engel T,Hatazaki S,Tanaka K,et al. Deletion of Puma proleets hipp- ocampal neurons in a model of severe status epileptieus[J]. Neuro- science,2010,168 (2) :443 - 450.
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基础医学与临床
2011年 第9期

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