摘要
目的比较初治活动性肺结核两种化疗方案的疗效与安全性。方法对某疾病预防控制中心6234例初治活动性肺结核患者资料进行回顾分析,按服药方法的不同分为A组(隔日服药)和B组(每日服药),对两组临床疗效和不良反应进行比较分析。结果 A组总的痊愈率和有效率高于B组,差异有统计学意义(χ2=14.37、18.73,均P<0.01),但B组65岁以上年龄段痊愈率高于A组,差异有统计学意义(χ2=7.66、5.15,P<0.01和P<0.05);A组不良反应总发生率高于B组,差异有统计学意义(χ2=110.07,P<0.01)。结论初治活动性肺结核隔日服药方案总体疗效优于每日服药方案,但对高龄患者的疗效不如后者,而且不良反应也较多较重。
Objective To compare the efficacy and safety of two chemotherapy to the new active pulmonary tuberculosis cases.Methods 6234 cases with the new active pulmonary tuberculosis were reviewed.Those cases were assigned to group A（take medicine on alternate days） and group B（take medicine daily）.To compare and analyse two groups in the clinical efficacy and the incidence of adverse effect.Results The cure rate and the effect rate in group A were significantly higher than those in group B（χ2=14.37、18.73,all P0.01）.But,the cure rate of the patients aged above 65 years old in group B were significantly higher than those in group A（χ2=7.66、5.15,P0.01 and P0.05）.The incidence of adverse effect in group A were significantly higher than that in group B（χ2=110.07,P0.01）.Conclusion In treatment to the new active pulmonary tuberculosis cases,chemotherapy A（take medicine on alternate days） is more effective than chemotherapy B（take medicine daily）.But,the former is not as effective as the latter in treatment to the old patients.In addition,the adverse effect of chemotherapy A is more and heavier than that of chemotherapy B.
出处
《临床肺科杂志》
2011年第9期1399-1401,共3页
Journal of Clinical Pulmonary Medicine
关键词
肺结核
化疗
疗效
安全性
Pulmonary Tuberculosis
Chemotherapy
Efficacy
Safety
