摘要
目的探讨血浆同型半胱氨酸水平(Hcy)和不同分型脑梗死之间的关系及脑梗死患者给予维生素B12和叶酸治疗前、后Hcy水平变化及其对预后的影响。方法检测206例脑梗死患者和51例正常人Hcy水平,并对脑梗死患者进行神经功能缺损评分(NIHSS)和进行分为进展性患者组、非进展性患者组,初发患者组和复发患者组,腔隙性脑梗死和脑血栓形成组,中青年患者组和老年患者组,观察各组的血浆同型半胱氨酸水平、NIHSS评分和给予维生素B12联合叶酸治疗,治疗4周后复测Hcy水平,并再次进行NIHSS评分。结果脑梗死患者组与对照组、进展性脑梗死患者组与非进展性患者组、初发患者组与复发性患者组、腔隙性脑梗死患者组与脑血栓形成组、中青年患者组与老年患者组的Hcy水平及NIHSS评分存在明显差异(P<0.01或P<0.05);以上不同分型脑梗死患者组与对照组的Hcy水平比较均存在显著差异(P<0.01),予以补充叶酸和维生素B12治疗后,脑梗死患者组Hcy水平明显下降,NIHSS评分显著降低(P<0.01)。结论以上各型脑梗死患者血浆Hcy水平显著升高,高同型半胱氨酸(Hhcy)是脑梗死患者的发生、发展、复发、病情程度、疾病转归的一个重要相关因素;脑梗死患者随年龄的增高Hcy水平显著升高;补充叶酸和维生素B12治疗有助于血浆Hcy水平的下降。
Objective To explore the relationship of plasma homocysteine（Hcy） and different points between cerebral infarction and cerebral infarction were treated with vitamin B12 and folic acid before and after treatment Hcy level and its effect on prognosis.Methods Detected 206 cases of cerebral infarction and 51 patients with normal Hcy levels,and cerebral infarction in patients with neurologic deficit score（NIHSS） and the progress of patients were randomly divided into two groups,patients with non-progressive group,primary group and relapse group,lacunar infarction and cerebral thrombosis,young and old patients were observed in each group,plasma homocysteine levels,NIHSS score were observed and give vitamin B12 and folic acid treatment,treatment for 4 weeks after the retest Hcy levels and NIHSS score again.Results Cerebral infarction group and the control group,patients with progressive cerebral infarction group and in patients with non-progressive group,primary group and recurrent group,patients with lacunar infarction and cerebral thrombosis group,middle-aged and elderly patients were Hcy levels in patients group and the NIHSS score were significantly different（P〈0.01 or P〈0.05）;More different type cerebral infarction group and the control group compared Hcy levels were significantly different（P〈0.01）,folic acid and supplemented Vitamin B12 treatment,cerebral infarction group Hcy level decreased significantly,NIHSS scores were significantly lower（P〈0.01）.Conclusions These various types of cerebral infarction was significantly increased plasma levels of Hcy,homocysteine（Hhcy） is an important related factors in the occurrence of cerebral infarction,development,recurrence,severity or prognosis of diseases;cerebral infarction patients＇ age increase and Hcy levels were significantly increased;Added folic acid and vitamin B12 treatment helps to decrease the level of plasma Hcy.
出处
《医药论坛杂志》
2011年第12期54-58,共5页
Journal of Medical Forum
作者简介
通讯作者：张东锋Email：zkzdf2006@163．com
