摘要
将丝素蛋白(SF)与聚丙烯酸(PAA)共混,制备丝素蛋白/聚丙烯酸(SF/PAA)共混膜;然后将此共混膜进行改性及矿化处理后,放置于(37±0.5)℃人体仿生液中24h,诱导合成丝素蛋白/羟基磷灰石(SF/HA)复合材料。利用傅里叶红外(FTIR)、X-射线衍射(XRD)、环境扫描电镜(ESEM)以及X射线能谱(EDX)对复合材料进行表征。结果表明,丝素蛋白分子与聚丙烯酸分子之间存在较强的相互作用,共混膜在人体仿生液中可以诱导沉积羟基磷灰石;聚丙烯酸的加入以及改性处理都可使丝素蛋白的结构转变为β-折叠,这种转变对羟基磷灰石生长起着重要作用。
The blend membranes of silk fibroin（SF） and polyacrylic acid（PAA） were prepared by blending polyacrylic acid with silk fibroin.After modification and mineralization process,the blend membranes were immersed into simulated body fluid（SBF） for 24 h to induce hydroxyapatite deposition at（37±0.5）℃.The structure and properties of the composite materials were investigated by Fourier transform infrared（FTIR）,X-ray diffraction（XRD）,environment scanning electron microscopy（ESEM） and energy dispersive X-ray spectrometer（EDX）.The results showed that there is a strong interaction between silk fibroin（SF） and polyacrylic acid（PAA）,the hydroxyapatite can be induced to deposit in the simulated body fluid by the blend membranes.The silk fibroin in the blend membrane was predominantly in a β-sheet,which was induced not only by the addition of PAA but also by the ethanol treatment and this played the key role in hydroxyapatite crystal growth.
出处
《化学世界》
CAS
CSCD
北大核心
2011年第7期407-412,共6页
Chemical World
基金
安徽省自然科学基金资助项目(070414193)
安徽省重实验室中青年骨干专项资助(2007)
关键词
羟基磷灰石
丝素蛋白
复合材料
人体仿生液
hydroxyapatite
silk fibroin
composite material
simulated body fluid
作者简介
马新兰（1984-），女，安徽宣城人，硕士，主要从事功能高分子材料和生物可降能材料研究。E—mail：maxinlanl26@126．com.
