摘要
目的 探讨妊娠期骨密度和骨代谢的变化。方法 对合肥市健康脑力劳动孕妇63例和非孕对照组21例分别测定桡骨骨密度(BMD)、血钙(Ca)、磷(P)、碱性磷酸酶(ALP)、骨钙素(BGP)以及尿羟脯氨酸/肌酐(HP/Cr)和尿钙/肌酐(Ca/Cr)比值。结果 ①孕期桡骨骨密度无明显变化,与非孕对照组比较有下降,但差异无显著性(P>005);②血Ca和P浓度孕期与对照组比较,差异无显著性(P>005);③血ALP和BGP在晚孕组明显升高,与非孕对照组和早、中孕组比较差异有显著性(P均<005);④尿HP/Cr和Ca/Cr在孕期有随孕周增加而升高的趋势,但各孕组间及与对照组比较差异无显著性(P均>005)。结论 妊娠期骨密度有下降,但无明显改变。而骨代谢生化指标在晚孕期变化明显,显示晚孕期骨转换率增加。
Objective To explore the changes in bone mineral density and biochemical markers of bone metabolism in normal pregnancy. Methods Bone mineral density(BMD) and serum concentrations of calcium(Ca), phosphorous(P), alkaline phosphatase(ALP), osteocalcin(BGP) were measured in 63 normal manual working pregnant women and 21 normal fertile mental working women. Among the pregnant women, 21 were studied during the first trimester (5～13 weeks), 21 during the second trimester (>13～28 weeks) and 21 during the third trimester(>28 weeks). In addition fasting urinary hydroxyproline/creatinine (Hp/Cr) and calcium/creatinine (Ca/Cr) ratio were measured in these subjects. Results No significant differences in BMD and serum concentrations of Ca and P were found during pregnancy ( P >0 05). Urinary Hp/Cr and Ca/Cr ratio tended to rise through pregnancy to term. But there was no significant difference among 4 groups( P >0 05). Serum concentrations of ALP and BGP in first and second trimesters were similar to those in nonpregnant wonen, but they rose rapidly in third trimester. There was significant difference between the third trimester group and the other groups ( P <0 05). Conclusion Pregnancy had not a significant effect on BMD. Changes in serum and urine markers of bone formation and resorption suggest that bone turnover may be inhabited in first and second trimesters, but significantly increased in third trimester.
出处
《安徽医科大学学报》
CAS
1999年第6期437-439,共3页
Acta Universitatis Medicinalis Anhui
关键词
妊娠期
骨密度
骨代谢
生化指标
pregnancy
bone and bone tissue/metabolism
bone mineral density
