摘要
本文测定了妊娠晚期及分娩后妇女（３１例）及相应年龄非妊娠妇女（４８例）血清中２５羟基维生素Ｄ３（２５ＯＨＤ３）、骨钙素（ＢＧＰ）的水平，尿羟脯氨酸与肌酐（ＨＯＰ／Ｃｒ）、钙与肌酐（Ｃａ／Ｃｒ）、Ⅰ型胶原交联Ｎ末端肽与肌酐（ＮＴＸ／Ｃｒ）比值。结果显示：血清２５ＯＨＤ３水平，在妊娠晚期，分娩后４２天明显低于非妊娠妇女（Ｐ＜０．０１）。血清ＢＧＰ水平，在妊娠晚期、分娩后４２天显著低于非妊娠妇女（Ｐ＜０．０１）。尿ＨＯＰ／Ｃｒ比值，在妊娠晚期，分娩后４２天明显高于非妊娠妇女（Ｐ＜０．０１），尿Ｃａ／Ｃｒ比值，在妊娠晚期明显高于非妊娠妇女（Ｐ＜０．０５），产后明显低于非妊娠妇女（Ｐ＜０．０１）。尿ＮＴＸ／Ｃｒ比值，在妊娠晚期，分娩后４２天非常显著高于非妊娠妇女（Ｐ＜０．００１）。以上研究结果表明：孕妇在妊娠晚期及分娩后４２天处于维生素Ｄ缺乏和负钙平衡状态，骨吸收明显增加，骨形成明显降低。
Serum levels of osteocalin(BGP),25 hydroxyvitamin D 3(25OHD 3)and the ratio of urine type Ⅰ collagen crosslinked N telopeptides(NTX),hydroxyproline(HOP)and calcium(Ca) to urine creatinine(Cr)were measured in 31 late term pregnant and postpartum women,and also in another 48 healthy non pregnant women as controls.The results showed that serum levels of 25 OHD 3 and BGP significantly decreased( P <0.01)in late term pregnant and postpartum women while ratio of urine HOP/Cr,Ca/Cr and NTX/Cr significantly increased ( P <0 01)in late term and postpartum women.This study demonstrates that there is vitamin D deficiency and negative calcium balance in late term pregnant and pastpartum women;bone resorption significantly increases and bone formation significantly decreases in these women.
出处
《中国骨质疏松杂志》
CAS
CSCD
1999年第2期21-23,共3页
Chinese Journal of Osteoporosis
