摘要
目的:制备司帕沙星(SF)温敏性耳用原位凝胶(ISG),对其体外性质进行考察,为研发SF新制剂奠定基础。方法:以泊洛沙姆407与188(质量比为3:4)为基质,用冷法制备SF-ISG。对其体外胶凝温度、胶凝强度及生物黏附性等主要物理性质进行考察,并对其质量控制进行了初步探索。结果:本品具有耳用ISG要求的合适的胶凝温度,胶凝强度理想,生物黏附性较强。主要质量评价指标简单易行,并符合相关规定。结论:SF温敏性耳用ISG制备简单,性质理想,值得进一步研发。
To prepare sparfloxacin （SF） temperature-sensitive in-situ gel （ISG） for ear application and study its quality in vitro in order to develop a new preparation of SF. Method： SF-ISG was prepared by cooling method using poloxmer 407 and 188 with mass ratio of 3：4 as the base. The in vitro properties of the gel, including gelling temperature, gelling strength and bioadhesive were studied and the quality of the gel was also evaluated. Result： The main in vitro properties of the gel were all promising for ear application. The quality of the gel met relative rules. Conclusion： SF temperature-sensitive ISG with simple preparation process and good in vitro quality is valuable to be studied further.
出处
《中国药师》
CAS
2011年第7期994-995,共2页
China Pharmacist
关键词
司帕沙星
温敏性
耳用原位凝胶
质量评定
Sparfloxacin
Temperature-sensitive
In-situ gel for ear application
Quality evaluation
作者简介
通讯作者：谢志勇 Tel：15072383374 E-mail：xiezhiyanyan@163．com
