摘要
为了给鸡球虫早熟弱毒疫苗的开发提供依据,对柔嫩艾美耳球虫(Eim eria tenella) 北京株经10 代早熟选育获得的早熟株的内生发育研究发现,其第2 代裂殖生殖发育较快,第2 代裂殖体含裂殖子较少,提前进入配子生殖,从而造成卵囊“早熟”。该早熟株致病性大大下降,经口感染10×104 个/只的致病性仅相当于剂量0.1×104 个/只亲本毒株的致病性。该虫株可作为研制早熟弱毒苗用虫株。
One precocious strain was derived from the Beijing strain of E.tenella. Examination of endogenous developmental stages suggested that the development of second generation schizogony of the precocious strain was earlier and the schizozoites fewer than that of the parental strain. In addition, the pathogenicity of precocious strain was found to be attenuated markedly. The inoculation effect of 10×10 4 oocysts of the precocious strain appears similar to that of 0.1×10 4 oocysts of the parental strain.
出处
《中国兽医学报》
CAS
CSCD
北大核心
1999年第6期569-571,共3页
Chinese Journal of Veterinary Science
基金
国家攀登计划畜禽重大疫病防治项目
关键词
柔嫩艾美耳球虫
早熟株
致病性
内生发育
Eimeria tenella
precocious strain
pathogenicity
endogenous developmental stage
