摘要
目的：探讨血管生成与腋淋巴结阴性乳腺癌（ＡＮＮＢＣ） 临床病理及预后关系，为ＡＮＮＢＣ 寻求一种新的预后因子。方法：选择８０ 例随访资料完整的根治或改良根治术后的ＡＮＮＢＣ 女病人（ 中位随访期８ 年，３５ 例术后实施了辅助治疗，４５ 例未接受辅助治疗） 的石蜡标本，用免疫组化方法染色微血管及检测血管内皮生长因子（ＶＥＧＦ）表达， 单因素和多因素方法分析肿瘤微血管密度（ ＭＶＤ） 和ＶＥＧＦ 的表达对ＡＮＮＢＣ 预后的关系。结果： 全部病例ＭＶＤ 平均值为３５－９９±２０－２７ ，ＶＥＧＦ 阳性率为３６－２５ ％ ， 两者均与一般临床病理因素无关， 高复发转移组或ＶＥＧＦ表达阳性组ＭＶＤ 显著高于无病生存组或ＶＥＧＦ 表达阴性组（ Ｐ＜ ０－０１） ，高ＭＶＤ 组（ＭＶＤ ＞ ３５） 或ＶＥＧＦ 阳性组ＯＳ 和ＤＦＳ 曲线低于低ＭＶＤ 组（ＭＶＤ≤３５） 及ＶＥＧＦ 阴性组，有统计学差异（ Ｐ＜ ０－０５ 或Ｐ＜ ０－０１） ，对术后未加辅助治疗的４５ 例病人分析，其结果也一致。分析术后加辅助治疗的３５ 例患者，只有ＶＥＧＦ 阴阳两组间ＤＦＳ 有差异。结论：ＶＥＧＦ 阳性表达者血管生成活跃，ＭＶＤ 值高，高ＭＶＤ、ＶＥＧＦ 表达阳性的ＡＮＮＢＣ 预后差，术?
Objective:To determine the relation of microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) with the prognosis of axillary node negative breast carcinoma (ANNBC) for searching for new prognostic factors.Methods:Eighty specimens resected from patients with ANNBC were investigated by staining with a monoclonal antibody against FVⅢ RA and polyclonal antibody against VEGF. Correlations between the expression of VEGF,MVD and several of clinicopathologic factors were studied.Results:The mean of MVD was 35 99±20 27 in all patients.The positive rate of VEGF was 36 25%.Both of them were not correlated with the clinicopathological factors. MVD was significantly higher in VEGF positive tumors or relapsed or metastatic group than in VEGF negative tumors or disease free survival group. Moreover, patients with higher MVD or VEGF positive tumors had lower disease free survival (DFS) or overall survival (OS) than those with lower MVD or VEGF negative tumors. When those (45 cases) without adjuvant therapies after surgery were analyzed, the results were the same.But OS of them (35 cases) with adjuvant therapies had no significiant difference between high and low MVD group, and between VEGF positive and negative group.DFS was the same among VEGF positive and negative group. Multivariate analysis indicated that MVD, the expression of VEGF and tumor size were independent prognostic factors in patients with ANNBC. Conclusions:MVD, the expression of VEGF may be good prognostic indicators for patients with ANNBC and adjuvant therapies after surgery or antiangiogenic therapy may be useful to improve the prognosis of patients with high MVD or VEGF positive tumors.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第5期566-569,共4页
Chinese Journal of Cancer
关键词
乳腺癌
血管生成
ANNBC
病理
预后
Angiogenesis
Capillaries
Vascular endothelial growth factor
Breast neoplasms
Prognosis
