摘要
目的探讨微血管生成与腋淋巴结阴性乳腺癌（ＡＮＮＢＣ）临床病理及预后关系。方法免疫组化方法检测１２０例ＡＮＮＢＣ石蜡标本中微血管密度（ＭＶＤ），分析ＭＶＤ与临床病理因素及无复发生存率（ＲＦＳ）、无转移生存率（ＭＦＳ）和总体生存率（ＯＳ）的关系。结果ＭＶＤ平均值３８２１±１８７２，与多种临床病理因素无关；复发转移ＡＮＮＢＣＭＶＤ值显著高于无病生存者；高ＭＶＤ组（ＭＶＤ＞３８）ＯＳ、ＲＦＳ、ＭＦＳ曲线低于低ＭＶＤ组（ＭＶＤ≤３８），差异有统计学意义（Ｐ＜０５或Ｐ＜００１）。结论微血管生成活跃ＡＮＮＢＣ预后不良，ＭＶＤ可能是ＡＮＮＢＣ一种较好的预后因子。
Objective To determine the relation of microvessel density (MVD) to the prognosis and the clinicopathological factors in axillary node negative breast cancer (ANNBC).Methods MVD in 120 cases paraffin specimens of ANNBC.were examinated using imminohistochemistry technique.The relationship between MVD and overall survival (OS),relapsefree survival (RFS),metastasis free survival (MFS) were analysed,respectively,as well as it was done between MVD and five clinicopathological factors.Results The mean MVD was 38 21±18 72.It didn't relate to those clinicopathological factors.MVD in relapse and metastasis group which was apparently higher than that in desease free group;OS,RFS,MFS curve in higher MVD group (MD>38) were significiantly lower those that in lower MVD group (MVD≤38),respectively;COX model indicated that MVD was an independent prognostic factor in ANNBC.Conclusion MVD may be a good prognostic indicator for patients with ANNBC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第4期272-274,共3页
Cancer Research on Prevention and Treatment
