摘要
在不同生物体,如病毒、植物、真菌和哺乳动物中,几百种含Kelch构象的蛋白质已经被鉴定出来了,但大部分此类蛋白质的功能未知.而在哺乳动物中,已经有接近41种Kelch蛋白被报道.这些蛋白质在体内参与了很多重要的生理过程.根据Kelch蛋白的域结构不同,把这些哺乳动物中的Kelch蛋白分成了三类(BTB/Kelch蛋白,只含有Kelch结构域的蛋白质,及含其他结构域的Kelch蛋白),并把其已知的功能大致划分为5类:介导蛋白质-蛋白质的相互作用、参与蛋白质降解、信号传导、胞外功能及其他等.另外还认为Keap 1的Kelch结构域其晶体结构应该是研究哺乳动物Kelch蛋白的一个很好的参考模型.
Hundreds of proteins with Kelch motif have been identified in diverse organisms including viruses, plants, fungi and mammals. Although most of the Kelch proteins are not functionally characterized at present, some of the known Kelch proteins seemed to function diversely in vivo. In mammals, nearly 41 Kelch proteins have been reported and proved to mediate the protein-protein interactions, protein degradation, and gene expression and signal transmission and so on. It was proposed that the crystal structure of Kelch domain of Keap 1 could be a preferable model for researching Kelch proteins in mammals. And it was also divided these mammal Kelch proteins into three groups according to their domain organizations and paid much attention to summarize their known function in vivo.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2011年第3期210-217,共8页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目(30770478)~~
作者简介
通讯联系人．Tel：010-58807365．E-mail：weiq@bnu．edu．cn
