摘要
目的探讨磷酸肌酸钠对小儿病毒性心肌炎的临床疗效，为改善该病预后以及寻求适宜的治疗药物提供依据。方法回顾性分析我院2006年1月-2011年2月收治的235例VMC患者的临床资料，根据其治疗方案将患儿分为治疗组和对照组，治疗组定义为给予维生素C、复方丹参注射液和磷酸肌酸钠治疗；对照组定义为给予维生素C和复方丹参注射液治疗。对患儿的发病性别、发病年龄、发病季节、前驱感染史、临床症状和体征、辅助检查（包括ECG和HOLTER检查、心肌酶检查等）及临床疗效等情况进行分析比较。结果治疗组从治疗的总有效率、ECG和HOLTER的阳性检出情况以及心肌酶CK—MB变化等方面都优于对照组，两组总有效率比较差异有统计学意义（X2=9．485，P〈O．05）。结论常规治疗加用磷酸肌酸钠取得较好疗效，可将磷酸肌酸钠作为辅治小儿VMC药物。
Objective To discuss sodium phosphocreatine against the disease clinical curative effect of VMC., In order to provide clinical basis for the future improving outcomes and appropriate cure medicine of VMC. Methods we collected and retrospective analyzed clinical data of 235 patients who had been proved to be VMC from 2006.1 to 2011.2 of Zhengzhou city children＇s hospital Divided the patients into two groups to observe the medicine curative effect： control group gave vitaminC,Compound danshen, therapy group gave vita- minC,Compound danshen and sodium phosphocreatine. On the patients onset gender, age, disease pathogenesis season, precursor infec- tion history, clinical symptoms and signs, auxiliary examination （including ECG and HOLTER inspection, myocardial enzymes check, chest radiograph and heart color dopplar ultrasound examination, virus antibody detection, cTnI, cTnT, CRP, NT - proBNP inspection and routine blood, etc.） and clinical curative effect and other circumstances were compared. Results All the results of ECG, HOLTER and cardiac muscle enzyme CK-MB disappearance were better in treatment group than in control group. There was a significant difference between these two groups（ X2=9.455, P 〈0.05） o Conclusions On the grounding of conventional therapy, sodium phosphocreatine can action an assisting medicine.
关键词
病毒性心肌炎
小儿
磷酸肌酸钠
Viralm yocarditis
Children
Sodium phosphocreatine
