摘要
目的利用改良的血栓弹力图技术研究高龄慢性肾脏病(CKD)患者凝血功能变化。方法选取我院南楼临床部住院的高龄非透析CKD患者32例为CKD组,选取同期住院的高龄非CKD患者38例为对照组。对比分析两组患者血栓弹力图及常规凝血指标变化。结果与对照组比较,CKD组患者Kthrombin显著减少(1.38±0.29vs1.94±0.50min),MAthrombin、综合凝血指数、AngleFibrin、MAFibrin和血浆纤维蛋白原显著增加(64.40±4.46vs58.53±4.15mm)、(7.47±0.81vs6.68±0.84)、(62.95±6.29vs54.60±8.00deg)、(20.57±10.89vs11.15±4.50mm)、(3.87±0.99vs3.24±0.68g/L),差异均有统计学意义(P<0.01)。结论高龄CKD患者存在高凝状态,CKD是综合凝血指数升高的独立危险因素。
Objective To investigate the changes of coagulative function in elderly patients with chronic kidney disease（CKD）by using thrombelastography（TEG）.Methods Thirty-two non-dialysis CKD elderly patients（mean age 84.61 years）and 38 patients without CKD（mean age 85.03 years）designed as CKD group and control group.Comparative analysis on the thrombelastogram and conventional blood coagulative parameters were used in the two groups.Results Compared with the control group,Kthrombin of CKD group was significantly decreased（P0.01）,while MAthrombin,AngleFibrin,MAFibrin and the level of serum fibrinogen were significantly increased（P0.01）.Conclusions The elderly patients with CKD were in hypercoagulable state,CKD was independent risk factor of clot index（CI）.
出处
《中华保健医学杂志》
2011年第1期15-18,共4页
Chinese Journal of Health Care and Medicine
关键词
慢性肾脏病
凝血
血栓弹力图
Chronic kidney disease
Coagulation
Thrombelastography
