摘要
目的观察加味四君子汤对接受FOLFOX4(奥沙利铂+亚叶酸钙+5-氟尿嘧啶)方案化疗的大肠癌患者免疫功能的影响。方法 45例大肠癌患者随机分为单纯化疗组(22例)和中药加化疗组(23例)。单纯化疗组用FOLFOX4方案化疗,中药加化疗组在该方案化疗的基础上口服加味四君子汤治疗,疗程为2个化疗周期。在化疗前及两周期化疗后采用免疫荧光染色及流式细胞仪检测T淋巴细胞亚群以及NK细胞百分比等免疫指标,观察两组化疗前后免疫功能变化;进行KPS评分和体重测量;评定化疗期间出现的各种毒副反应。结果两周期化疗后,单纯化疗组CD4、CD4/CD8水平明显下降(P<0.05),而中药加化疗组CD3、CD4、CD4/CD8水平较化疗前有所增加(P<0.05)。两组间比较,化疗后中药加化疗组CD4、CD4/CD8水平较单纯化疗组高(P<0.05)。与单纯化疗组比较,中药加化疗组能抑制白细胞减少,减轻恶心、呕吐等化疗毒副反应,稳定KPS评分和体重,差异均有统计学意义(P<0.05)。结论加味四君子汤能改善行FOLFOX4方案化疗的大肠癌患者的免疫功能,提高生活质量,减少恶心、呕吐等化疗毒副反应。
Objective To observe the effect of modified Sijunzi Decoction （SJZD） on immune function in patients with colorectal cancer undergoing chemotherapy （CM） with FOLFOX4 protocol （oxaliplatin ＋ calcium folinate＋ 5-fluorouracil）. Methods Forty-five patients with colorectal cancer were randomly assigned to two groups,the 22 in the control group treated with CM alone and the 23 in the treated group treated with CM plus SJZD. The therapeutic course for both groups was 2 chemotherapy cycles. Immunologic indices,including T-lymphocyte subgroup and NK cell proportion were detected before and after treatment using immunofluorescence stain and flow cytometry. Meantime,patients＇ quality of life （QOL） was scaled by KPS scoring,body mass was weighed,side and toxic effects of chemotherapy were recorded. Results Compared with pre-treatment,CD4 and CD4/CD8 significantly decreased after treatment in the control group （P0.05）,while in the treated group,CD3,CD4 and CD4/CD8 increased significantly （P0.05）. In addition,CD4 and CD4/CD8 were much higher in the treated group than in the control group （P0.05）. Compared with the control group,the treated group had stabilized KPS score and body weight,and reduced chemotherapeutic toxicity shown as higher level of leucocyte amount,less symptoms of nausea and vomiting （P0.05）. Conclusion SJZD could improve the immune function and QOL of colorectal cancer patients undergoing FOLFOX4,and reduce the side effects of CM.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2011年第2期164-167,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
加味四君子汤
大肠癌
化疗
免疫功能
生活质量
modified Sijunzi Decoction
colorectal cancer
chemotherapy
immune function
quality of life
作者简介
通讯作者：肖寒，Tel：0510—88682212，E-mail：hart_x1981@163．com
